Clomipramine hydrochloride

Pricing Availability   Qty
Cat.No. 0457 - Clomipramine hydrochloride | C19H23ClN2.HCl | CAS No. 17321-77-6
Description: 5-HT reuptake inhibitor
Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (2)

Biological Activity

Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.

Technical Data

M. Wt 351.32
Formula C19H23ClN2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 17321-77-6
PubChem ID 68539
InChI Key WIMWMKZEIBHDTH-UHFFFAOYSA-N
Smiles Cl.CN(C)CCCN1C2=CC(Cl)=CC=C2CCC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136 PMID: 2178909

Ortiz and Artiga (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluox. Br.J.Pharmacol. 105 941 PMID: 1387022

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Merck Index 12 2447


If you know of a relevant reference for Clomipramine hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT Transporter Inhibitors

Keywords: Clomipramine hydrochloride, Clomipramine hydrochloride supplier, 5HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, 0457, Tocris Bioscience

3 Citations for Clomipramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Clomipramine hydrochloride include:

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Eur J Neurosci 352 53 PMID: 25332454

Duncan et al (2010) The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biomed Sci 31 1646 PMID: 20525077

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126


Do you know of a great paper that uses Clomipramine hydrochloride from Tocris? Please let us know.

Reviews for Clomipramine hydrochloride

There are currently no reviews for this product. Be the first to review Clomipramine hydrochloride and earn rewards!

Have you used Clomipramine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.