Discontinued Product

Cl-HIBO (Cat. No. 1673) has been withdrawn from sale for commercial reasons.
Description: GluA1 and GluA2 selective AMPA agonist
Alternative Names: 4-Chlorohomoibotenic acid
Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
Purity: ≥99% (HPLC)
Literature (10)

Biological Activity for Cl-HIBO

Cl-HIBO is a subtype-selective and strongly desensitizing AMPA receptor agonist; selective for GluA1 and GluA2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluA1-4 receptors respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for Cl-HIBO

M. Wt 206.59
Formula C6H7ClN2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 909400-43-7
PubChem ID 4694356
Smiles ClC1=C(CC(C(O)=O)N)ON=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Cl-HIBO

References are publications that support the biological activity of the product.

Bjerrum et al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246 PMID: 12747796

Kristensen et al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7

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Keywords: Cl-HIBO, Cl-HIBO supplier, Subtype-selective, AMPA, agonists, GluR1, GluR2, Glutamate, Receptors, iGluR, Ionotropic, Chloro-homoibotenic, acid, GluA1, GluA2, 4-Chlorohomoibotenic, 1673, Tocris Bioscience

Citations for Cl-HIBO

Citations are publications that use Tocris products.

Currently there are no citations for Cl-HIBO.

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