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Submit ReviewCl-HIBO
Description: GluA1 and GluA2 selective AMPA agonist
Alternative Names: 4-Chlorohomoibotenic acid
Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
Purity: ≥99% (HPLC)
Biological Activity for Cl-HIBO
Cl-HIBO is a subtype-selective and strongly desensitizing AMPA receptor agonist; selective for GluA1 and GluA2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluA1-4 receptors respectively).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for Cl-HIBO
| M. Wt | 206.59 |
| Formula | C6H7ClN2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 909400-43-7 |
| PubChem ID | 4694356 |
| InChI Key | FDSXCQTXUSQQFH-UHFFFAOYSA-N |
| Smiles | ClC1=C(CC(C(O)=O)N)ON=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cl-HIBO
References for Cl-HIBO
References are publications that support the biological activity of the product.
Bjerrum et al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246 PMID: 12747796
Kristensen et al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7
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Keywords: Cl-HIBO, Cl-HIBO supplier, Subtype-selective, AMPA, agonists, GluR1, GluR2, Glutamate, Receptors, iGluR, Ionotropic, Chloro-homoibotenic, acid, GluA1, GluA2, 4-Chlorohomoibotenic, 1673, Tocris Bioscience
Citations for Cl-HIBO
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