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Description: GluA1 and GluA2 selective AMPA agonist
Alternative Names: 4-Chlorohomoibotenic acid
Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
Purity: ≥99% (HPLC)
Biological Activity
Subtype-selective and strongly desensitizing AMPA receptor agonist; selective for GluA1 and GluA2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluA1-4 receptors respectively).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
| M. Wt | 206.59 |
| Formula | C6H7ClN2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 909400-43-7 |
| PubChem ID | 4694356 |
| InChI Key | FDSXCQTXUSQQFH-UHFFFAOYSA-N |
| Smiles | ClC1=C(CC(C(O)=O)N)ON=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.13 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 206.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 24.2 mL | 121.01 mL | 242.03 mL |
| 1 mM | 4.84 mL | 24.2 mL | 48.41 mL |
| 2 mM | 2.42 mL | 12.1 mL | 24.2 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.84 mL |
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References
References are publications that support the biological activity of the product.
Bjerrum et al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246 PMID: 12747796
Kristensen et al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7
If you know of a relevant reference for Cl-HIBO, please let us know.
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Keywords: Cl-HIBO, Cl-HIBO supplier, Subtype-selective, AMPA, agonists, GluR1, GluR2, Glutamate, Receptors, iGluR, Ionotropic, Chloro-homoibotenic, acid, GluA1, GluA2, 4-Chlorohomoibotenic, 1673, Tocris Bioscience
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