CJ 033466

Discontinued Product

CJ 033466 (Cat. No. 3089) has been withdrawn from sale for commercial reasons.
Cat.No. 3089 - CJ 033466 | C19H28ClN5O | CAS No. 519148-48-2
Description: Selective 5-HT4 partial agonist
Chemical Name: 5-Amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-piperidinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for CJ 033466

CJ 033466 is a potent and selective 5-HT4 partial agonist (EC50= 0.927 nM). Displays > 1000-fold selectivity for 5-HT4 over other 5-HT and D2 receptors. Exhibits gastroprokinetic effects in vivo following oral administration. Weakly blocks hERG (IC50 = 2.6 μM).

Technical Data for CJ 033466

M. Wt 377.91
Formula C19H28ClN5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 519148-48-2
PubChem ID 10429706
InChI Key ISKHMDNIWXPUGR-UHFFFAOYSA-N
Smiles ClC2=C(N)N1C(C(C(NCC3CCN(CC(C)C)CC3)=O)=C2)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CJ 033466

Certificate of Analysis / Product Datasheet
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Keywords: CJ 033466, CJ 033466 supplier, Selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, CJ033466, 3089, Tocris Bioscience

Citations for CJ 033466

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.