Pricing Availability   Qty
Description: Negative control for SIM1 (Cat. No. 7432)
Chemical Name: N,N'-(11-((2-(((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide)
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for cis-SIM1

cis-SIM1 is the negative control for SIM1 (Cat. No. 7432).

Licensing Information

Sold under licence from the University of Dundee

Technical Data for cis-SIM1

M. Wt 1618.82
Formula C79H98Cl2N14O13S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2719051-98-4
PubChem ID 156022817
Smiles CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCOCC(C)(COCCOCCOCCNC(=O)C[C@@H]1N=C(C3=C(SC(C)=C3C)N3C(C)=NN=C13)C1=CC=C(Cl)C=C1)COCC(=O)N[C@H](C(=O)N1C[C@@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1)C1=C(C)N=CS1)C(C)(C)C)N=C2C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for cis-SIM1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 161.88 100

Preparing Stock Solutions for cis-SIM1

The following data is based on the product molecular weight 1618.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.18 mL
5 mM 0.12 mL 0.62 mL 1.24 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for cis-SIM1

References are publications that support the biological activity of the product.

If you know of a relevant reference for cis-SIM1, please let us know.

Keywords: cis-SIM1, cis-SIM1 supplier, negative, controls, targeted, protein, degradation, degraders, VHL, von, hippel, lindau, E3, ligases, PROTAC, BET, Bromodomains, Protein, Degraders, 7433, Tocris Bioscience

Citations for cis-SIM1

Citations are publications that use Tocris products.

Currently there are no citations for cis-SIM1. Do you know of a great paper that uses cis-SIM1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Targeted Protein Degradation Poster

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