cis MZ 1

Pricing Availability Delivery Time Qty
Cat.No. 6155 - cis MZ 1 | C49H60ClN9O8S2 | CAS No. 1797406-72-4
Description: Negative Control for MZ1
Chemical Name: (2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2- f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.

Licensing Information

Sold under licence from the University of Dundee

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.

Technical Data

M. Wt 1002.64
Formula C49H60ClN9O8S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1797406-72-4
PubChem ID 124201820
InChI Key PTAMRJLIOCHJMQ-HADAFJFFSA-N
Smiles CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)S1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.26 100
ethanol 100.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1002.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1 mL 4.99 mL 9.97 mL
5 mM 0.2 mL 1 mL 1.99 mL
10 mM 0.1 mL 0.5 mL 1 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS.Chem.Biol. 10 1770 PMID: 26035625


If you know of a relevant reference for cis MZ 1, please let us know.

Keywords: cis MZ 1, supplier, cis, MZ1, MZ1, PROTAC, Proteolysis, targeted, chimeras, Bromodomain, BRD2, BRD3, BRD4, BET, proteins, JQ1, VHL, E3, ubiquitin, ligase, HIF-alpha, HIF-a, HIF-α, Ubiquitin, E3, Ligases, Hypoxia, Inducible, Factors, Bromodomains, HIF, PROTACs, Ubiquitin, E3, Ligases, Tocris Bioscience

Citations for cis MZ 1

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