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Description: TRPV6 inhibitor
Chemical Name: 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine ditrifluoroacetate
Purity: ≥98% (HPLC)

Biological Activity for cis-22a

cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Compound Libraries for cis-22a

cis-22a is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for cis-22a

M. Wt 563.54
Formula C22H29N3.2CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1819366-84-1
Smiles CC1=CC=CC([C@@H]2CC[C@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for cis-22a

Solvent Max Conc. mg/mL Max Conc. mM
water 56.35 100
DMSO 56.35 100

Preparing Stock Solutions for cis-22a

The following data is based on the product molecular weight 563.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.87 mL 17.74 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References for cis-22a

References are publications that support the biological activity of the product.

Cunha et al (2019) Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 10 1341 PMID: 31531207

Simonin et al (2015) Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 54 14748 PMID: 26457814

If you know of a relevant reference for cis-22a, please let us know.

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Citations for cis-22a

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