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cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 563.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.87 mL||17.74 mL|
|5 mM||0.35 mL||1.77 mL||3.55 mL|
|10 mM||0.18 mL||0.89 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
References are publications that support the biological activity of the product.
Cunha et al (2019) Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 10 1341 PMID: 31531207
Simonin et al (2015) Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 54 14748 PMID: 26457814
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Keywords: cis-22a, cis-22a supplier, cis22a, selective, TRPV6, inhibitors, inhibitor, inhibits, transient, receptor, potential, vanilloid, 6, TRPV, 7118, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.