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Submit ReviewCINPA 1
Discontinued Product
5605 has been discontinued.
View all Constitutive Androstane Receptor products.
Description: Potent CAR antagonist
Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Purity: ≥98% (HPLC)
Biological Activity for CINPA 1
CINPA 1 is a potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.
Compound Libraries for CINPA 1
CINPA 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CINPA 1
| M. Wt | 395.49 |
| Formula | C23H29N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 102636-74-8 |
| PubChem ID | 969470 |
| InChI Key | AYQBYSPEGRYKFA-UHFFFAOYSA-N |
| Smiles | O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CINPA 1
References for CINPA 1
References are publications that support the biological activity of the product.
Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878 PMID: 25762023
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Keywords: CINPA 1, CINPA 1 supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Constitutive, Androstane, Receptor, 5605, Tocris Bioscience
1 Citation for CINPA 1
Citations are publications that use Tocris products. Selected citations for CINPA 1 include:
Boussadia et al (2016) Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. Exp Neurol 283 39 PMID: 27240521
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