Home / Pharmacology / Nuclear Receptors / Constitutive Androstane Receptor / Constitutive Androstane Receptor Antagonists / CINPA 1

CINPA 1

Cat. No. 5605 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 5605 - CINPA 1 | C23H29N3O3 | CAS No. 102636-74-8
Description: Potent CAR antagonist
Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.

Compound Libraries

CINPA 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 395.49
Formula C23H29N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 102636-74-8
PubChem ID 969470
InChI Key AYQBYSPEGRYKFA-UHFFFAOYSA-N
Smiles O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100
ethanol 39.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878 PMID: 25762023

If you know of a relevant reference for CINPA 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Constitutive Androstane Receptor Antagonists

Keywords: CINPA 1, CINPA 1 supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Constitutive, Androstane, Receptor, 5605, Tocris Bioscience

Citations for CINPA 1

Citations are publications that use Tocris products.

Currently there are no citations for CINPA 1. Do you know of a great paper that uses CINPA 1 from Tocris? Please let us know.

Reviews for CINPA 1

There are currently no reviews for this product. Be the first to review CINPA 1 and earn rewards!

Have you used CINPA 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors