CINPA 1

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Cat.No. 5605 - CINPA 1 | C23H29N3O3 | CAS No. 102636-74-8
Description: Potent CAR antagonist
Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.

Compound Libraries

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Technical Data

M. Wt 395.49
Formula C23H29N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 102636-74-8
PubChem ID 969470
InChI Key AYQBYSPEGRYKFA-UHFFFAOYSA-N
Smiles O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100
ethanol 39.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878 PMID: 25762023


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View all Constitutive Androstane Receptor Antagonists

Keywords: CINPA1 CAR constitutive androstane receptors potent antagonists Constitutive Androstane Receptor

Citations for CINPA 1

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Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for CINPA 1

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