CINPA 1
Biological Activity
Potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.
Compound Libraries
CINPA 1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 395.49 |
| Formula | C23H29N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 102636-74-8 |
| PubChem ID | 969470 |
| InChI Key | AYQBYSPEGRYKFA-UHFFFAOYSA-N |
| Smiles | O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.55 | 100 | |
| ethanol | 39.55 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 395.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878 PMID: 25762023
If you know of a relevant reference for CINPA 1, please let us know.
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Keywords: CINPA 1, supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Constitutive, Androstane, Receptor, Constitutive, Androstane, Receptor, Tocris Bioscience
Citations for CINPA 1
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Nuclear Receptors Product Listing
A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
- Retinoic Acid Receptors
- Retinoid X Receptors
- Vitamin D Receptors
