CID 2011756

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Cat.No. 4644 - CID 2011756 | C22H21ClN2O3 | CAS No. 638156-11-3
Description: Pan protein kinase D (PKD) inhibitor; cell permeable
Chemical Name: 5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively). Cell permeable (EC50 = 10 μM for PKD1 inhibition). ATP-competitive.

Compound Libraries

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Technical Data

M. Wt 396.87
Formula C22H21ClN2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 638156-11-3
PubChem ID 2011756
InChI Key XQJWTJLJEYIUDZ-UHFFFAOYSA-N
Smiles O=C(NC3=CC=C(CN4CCOCC4)C=C3)C1=CC=C(C2=CC=CC(Cl)=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.84 50

Preparing Stock Solutions

The following data is based on the product molecular weight 396.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.6 mL 25.2 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sharlow et al (2011) Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One 6 e25134 PMID: 21998636


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Keywords: CID2011756 pan protein kinase D PKD inhibits inhibitors cell permeable ATP competitive Protein Kinase D

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Protein Kinases A, C, D and G
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  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for CID 2011756

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