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Pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 207.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.82 mL||24.12 mL||48.25 mL|
|5 mM||0.96 mL||4.82 mL||9.65 mL|
|10 mM||0.48 mL||2.41 mL||4.82 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Shen et al (2017) Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 8 505 PMID: 28680535
Yang et al (2017) Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 77 4626 PMID: 28684529
If you know of a relevant reference for Ciclopirox, please let us know.
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Keywords: Ciclopirox, Ciclopirox supplier, pan, histone, demethylase, inhibitors, inhibits, antifungal, anticancer, KDM, Histone, Demethylases, Antifungals, 6384, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases