Ciclopirox

Pricing Availability Delivery Time Qty
Cat.No. 6384 - Ciclopirox | C12H17NO2 | CAS No. 29342-05-0
Description: Pan-histone demethylase inhibitor
Chemical Name: 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.

Technical Data

M. Wt 207.27
Formula C12H17NO2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 29342-05-0
PubChem ID 2749
InChI Key SCKYRAXSEDYPSA-UHFFFAOYSA-N
Smiles CC1=CC(N(C(C2CCCCC2)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.73 100
ethanol 20.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 207.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.82 mL 24.12 mL 48.25 mL
5 mM 0.96 mL 4.82 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.82 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Shen et al (2017) Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 8 505 PMID: 28680535

Yang et al (2017) Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 77 4626 PMID: 28684529


If you know of a relevant reference for Ciclopirox, please let us know.

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Keywords: Ciclopirox, Ciclopirox supplier, pan, histone, demethylase, inhibitors, inhibits, antifungal, anticancer, KDM, Histone, Demethylases, 6384, Tocris Bioscience

Citations for Ciclopirox

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases