Pricing Availability   Qty
Description: Pan-histone demethylase inhibitor
Chemical Name: 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Ciclopirox

Ciclopirox is a pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.

Compound Libraries for Ciclopirox

Ciclopirox is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ciclopirox

M. Wt 207.27
Formula C12H17NO2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 29342-05-0
PubChem ID 2749
Smiles CC1=CC(N(C(C2CCCCC2)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ciclopirox

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.73 100
ethanol 20.73 100

Preparing Stock Solutions for Ciclopirox

The following data is based on the product molecular weight 207.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.82 mL 24.12 mL 48.25 mL
5 mM 0.96 mL 4.82 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.82 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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References for Ciclopirox

References are publications that support the biological activity of the product.

Shen et al (2017) Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 8 505 PMID: 28680535

Yang et al (2017) Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 77 4626 PMID: 28684529

If you know of a relevant reference for Ciclopirox, please let us know.

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Keywords: Ciclopirox, Ciclopirox supplier, pan, histone, demethylase, inhibitors, inhibits, antifungal, anticancer, KDM, Histone, Demethylases, Antifungals, 6384, Tocris Bioscience

Citations for Ciclopirox

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Literature in this Area

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.