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Biological Activity for Ciclesonide
Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC90 = 6.3μM)..
Compound Libraries for Ciclesonide
Technical Data for Ciclesonide
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ciclesonide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ciclesonide
The following data is based on the product molecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.25 mL||18.49 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References for Ciclesonide
References are publications that support the biological activity of the product.
Stoeck et al (2004) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 309 249 PMID: 14718604
Matsuyama et al (2020) The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 95 e01648 PMID: 33055254
If you know of a relevant reference for Ciclesonide, please let us know.
Keywords: Ciclesonide, Ciclesonide supplier, Glucocorticoid, antiasthmatic, prodrug, anti-inflammatory, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Receptor, Coronavirus, 6357, Tocris Bioscience
Citations for Ciclesonide
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.