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Description: Glucocorticoid antiasthmatic prodrug
Chemical Name: (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Ciclesonide

Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC90 = 6.3μM)..

Compound Libraries for Ciclesonide

Ciclesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ciclesonide

M. Wt 540.7
Formula C32H44O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 126544-47-6
PubChem ID 6918155
Smiles [H][C@@]1(C2CCCCC2)O[C@]3([H])C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]3(C(COC(C(C)C)=O)=O)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ciclesonide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 54.07 100
ethanol 54.07 100

Preparing Stock Solutions for Ciclesonide

The following data is based on the product molecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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References for Ciclesonide

References are publications that support the biological activity of the product.

Stoeck et al (2004) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 309 249 PMID: 14718604

Matsuyama et al (2020) The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 95 e01648 PMID: 33055254

If you know of a relevant reference for Ciclesonide, please let us know.

Keywords: Ciclesonide, Ciclesonide supplier, Glucocorticoid, antiasthmatic, prodrug, anti-inflammatory, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Receptor, Coronavirus, 6357, Tocris Bioscience

Citations for Ciclesonide

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.