Ciclesonide

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Cat.No. 6357 - Ciclesonide | C32H44O7 | CAS No. 126544-47-6
Description: Glucocorticoid antiasthmatic prodrug
Chemical Name: (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory.

Technical Data

M. Wt 540.7
Formula C32H44O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 126544-47-6
PubChem ID 6918155
InChI Key LUKZNWIVRBCLON-GXOBDPJESA-N
Smiles [H][C@@]1(C2CCCCC2)O[C@]3([H])C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]3(C(COC(C(C)C)=O)=O)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.07 100
ethanol 54.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Stoeck et al (2004) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. J.Pharmacol.Exp.Ther. 309 249 PMID: 14718604


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Keywords: Ciclesonide, Ciclesonide supplier, Glucocorticoid, antiasthmatic, prodrug, anti-inflammatory, Receptor, 6357, Tocris Bioscience

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