Chlorpromazine hydrochloride

Discontinued Product

Unfortunately Chlorpromazine hydrochloride (Cat. No. 4097) has been withdrawn from sale for commercial reasons.
Cat.No. 4097 - Chlorpromazine hydrochloride | C17H19ClN2S.HCl | CAS No. 69-09-0
Description: Antipsychotic; D2 and H1 antagonist
Alternative Names: CPZ
Chemical Name: 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.

Technical Data

M. Wt 355.33
Formula C17H19ClN2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 69-09-0
Smiles ClC3=CC2=C(C=C3)SC1=CC=CC=C1N2CCCN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 355.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.14 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Martinez and Coleman (1990) A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int.J.Immunopharmacol. 12 185 PMID: 2329012

Eisenberg et al (2008) Differential interference of chlorpromazine with the membrane interactions of oncogenic K-ras and its effects on cell growth. J.Biol.Chem. 283 27279 PMID: 18693247

Chiara et al (2009) [3H]chlorpromazine photolabeling of the Torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry 48 10066 PMID: 19754159

Palacios et al (1993) Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Biochem.Biophys.Res.Comms. 196 280 PMID:

Cohen et al (1997) Characterization of the discriminative stimulus produced by the dopamine antagonist tiapride. J.Pharm.Exp.Ther. 283 573 PMID:

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Citations for Chlorpromazine hydrochloride

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Literature in this Area

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