Chlorpromazine hydrochloride

Discontinued Product

Chlorpromazine hydrochloride (Cat. No. 4097) has been withdrawn from sale for commercial reasons.
Cat.No. 4097 - Chlorpromazine hydrochloride | C17H19ClN2S.HCl | CAS No. 69-09-0
Description: Antipsychotic; D2 and H1 antagonist
Alternative Names: CPZ
Chemical Name: 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.

Technical Data

M. Wt 355.33
Formula C17H19ClN2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 69-09-0
Smiles ClC3=CC2=C(C=C3)SC1=CC=CC=C1N2CCCN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References

References are publications that support the biological activity of the product.

Martinez and Coleman (1990) A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int.J.Immunopharmacol. 12 185 PMID: 2329012

Eisenberg et al (2008) Differential interference of chlorpromazine with the membrane interactions of oncogenic K-ras and its effects on cell growth. J.Biol.Chem. 283 27279 PMID: 18693247

Chiara et al (2009) [3H]chlorpromazine photolabeling of the Torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry 48 10066 PMID: 19754159

Palacios et al (1993) Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Biochem.Biophys.Res.Comms. 196 280

Cohen et al (1997) Characterization of the discriminative stimulus produced by the dopamine antagonist tiapride. J.Pharm.Exp.Ther. 283 573

View Related Products by Target

Keywords: Chlorpromazine hydrochloride, Chlorpromazine hydrochloride supplier, Chlorpromazine, HCl, dopamine, D2, receptor, antagonist, histamine, H1, antagonists, CPZ, Miscellaneous, Compounds, 4097, Tocris Bioscience

Citations for Chlorpromazine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Chlorpromazine hydrochloride.

Reviews for Chlorpromazine hydrochloride

There are currently no reviews for this product. Be the first to review Chlorpromazine hydrochloride and earn rewards!

Have you used Chlorpromazine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells