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Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Martinez and Coleman (1990) A comparison of the effects of chlorprom. and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int.J.Immunopharmacol. 12 185 PMID: 2329012
Eisenberg et al (2008) Differential interference of chlorprom. with the membrane interactions of oncogenic K-ras and its effects on cell growth. J.Biol.Chem. 283 27279 PMID: 18693247
Chiara et al (2009) [3H]chlorpromazine photolabeling of the Torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry 48 10066 PMID: 19754159
Palacios et al (1993) Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Biochem.Biophys.Res.Comms. 196 280
Cohen et al (1997) Characterization of the discriminative stimulus produced by the DA antagonist tiapride. J.Pharm.Exp.Ther. 283 573
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