Discontinued ProductUnfortunately Chlorpromazine hydrochloride (Cat. No. 4097) has been withdrawn from sale for commercial reasons.
Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 355.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.81 mL||14.07 mL||28.14 mL|
|5 mM||0.56 mL||2.81 mL||5.63 mL|
|10 mM||0.28 mL||1.41 mL||2.81 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the products' biological activity.
Martinez and Coleman (1990) A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int.J.Immunopharmacol. 12 185 PMID: 2329012
Eisenberg et al (2008) Differential interference of chlorpromazine with the membrane interactions of oncogenic K-ras and its effects on cell growth. J.Biol.Chem. 283 27279 PMID: 18693247
Chiara et al (2009) [3H]chlorpromazine photolabeling of the Torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry 48 10066 PMID: 19754159
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