An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 611.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.17 mL||16.34 mL|
|5 mM||0.33 mL||1.63 mL||3.27 mL|
|10 mM||0.16 mL||0.82 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References are publications that support the products' biological activity.
Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397 PMID: 7911713
El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406 PMID: 8004384
El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917 PMID: 7858886
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Keywords: Chlorisondamine diiodide, supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine, diiodide, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
3 Citations for Chlorisondamine diiodide
Citations are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:
Sabharwal et al (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab 127 101 PMID: 24502705
Luyer et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond) 202 1023 PMID: 16216887
Sabharwal et al (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med 100 776 PMID: 25921929
Do you know of a great paper that uses Chlorisondamine diiodide from Tocris? If so please let us know.
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