Chlorisondamine diiodide

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Description: nAChR antagonist; slow offset
Alternative Names: 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide
Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide
Purity: ≥99% (HPLC)
Citations (4)
Literature (3)

Biological Activity for Chlorisondamine diiodide

An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Technical Data for Chlorisondamine diiodide

M. Wt 611.95
Formula C14H20Cl4I2N2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 96750-66-2
PubChem ID 16078959
Smiles [I-].[I-].C[N+](C)(C)CC[N+]1(C)CC2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Chlorisondamine diiodide

Solvent Max Conc. mg/mL Max Conc. mM
water 6.12 10

Preparing Stock Solutions for Chlorisondamine diiodide

The following data is based on the product molecular weight 611.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.34 mL 81.71 mL 163.41 mL
0.5 mM 3.27 mL 16.34 mL 32.68 mL
1 mM 1.63 mL 8.17 mL 16.34 mL
5 mM 0.33 mL 1.63 mL 3.27 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Chlorisondamine diiodide

Certificate of Analysis / Product Datasheet
Select another batch:

References for Chlorisondamine diiodide

References are publications that support the biological activity of the product.

Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397 PMID: 7911713

El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of DA from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406 PMID: 8004384

El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917 PMID: 7858886

If you know of a relevant reference for Chlorisondamine diiodide, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Non-selective) Antagonists

Keywords: Chlorisondamine diiodide, Chlorisondamine diiodide supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine, diiodide, (Non-selective), 1001, Tocris Bioscience

4 Citations for Chlorisondamine diiodide

Citations are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:

Bucci et al (2013) Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function. Br J Pharmacol 168 411 PMID: 22957757

Sabharwal et al (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med 100 776 PMID: 25921929

Luyer et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond) 202 1023 PMID: 16216887

Sabharwal et al (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab 127 101 PMID: 24502705

Do you know of a great paper that uses Chlorisondamine diiodide from Tocris? Please let us know.

Reviews for Chlorisondamine diiodide

There are currently no reviews for this product. Be the first to review Chlorisondamine diiodide and earn rewards!

Have you used Chlorisondamine diiodide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.