Chlorisondamine diiodide

Discontinued Product

Chlorisondamine diiodide (Cat. No. 1001) has been withdrawn from sale for commercial reasons.
Description: nAChR antagonist; slow offset
Alternative Names: 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide
Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (1)

Biological Activity for Chlorisondamine diiodide

An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Technical Data for Chlorisondamine diiodide

M. Wt 611.95
Formula C14H20Cl4I2N2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 96750-66-2
PubChem ID 16078959
InChI Key FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Smiles [I-].[I-].C[N+](C)(C)CC[N+]1(C)CC2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Chlorisondamine diiodide

Certificate of Analysis / Product Datasheet
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References for Chlorisondamine diiodide

References are publications that support the biological activity of the product.

Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397 PMID: 7911713

El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of DA from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406 PMID: 8004384

El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917 PMID: 7858886

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Keywords: Chlorisondamine diiodide, Chlorisondamine diiodide supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine, diiodide, (Non-selective), 1001, Tocris Bioscience

4 Citations for Chlorisondamine diiodide

Citations are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:

Sabharwal et al (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab 127 101 PMID: 24502705

Sabharwal et al (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med 100 776 PMID: 25921929

Bucci et al (2013) Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function. Br J Pharmacol 168 411 PMID: 22957757

Luyer et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond) 202 1023 PMID: 16216887


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.