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Submit ReviewCGK 733
Description: Induces apoptosis in prematurely senescent cells
Chemical Name: α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Purity: ≥98% (HPLC)
Biological Activity for CGK 733
Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
Technical Data for CGK 733
| M. Wt | 555.84 |
| Formula | C23H18Cl3FN4O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 905973-89-9 |
| PubChem ID | 6605258 |
| InChI Key | HLCDNLNLQNYZTK-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGK 733
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.58 | 100 |
Preparing Stock Solutions for CGK 733
The following data is based on the product molecular weight 555.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 9 mL | 17.99 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets for CGK 733
References for CGK 733
References are publications that support the biological activity of the product.
Crescenzi et al (2008) Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res. 14 1877 PMID: 18347191
Bhattacharya et al (2009) Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 21 509 PMID: 19136059
Alao and Sunnerhagen (2009) The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 10 4 PMID: 19903334
Won et al (2008) Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat.Chem.Biol. 4 431 PMID: 18560433
If you know of a relevant reference for CGK 733, please let us know.
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Keywords: CGK 733, CGK 733 supplier, CGK733, p21, antiproliferative, p53, Other, Apoptosis, 2639, Tocris Bioscience
3 Citations for CGK 733
Citations are publications that use Tocris products. Selected citations for CGK 733 include:
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408 PMID: 24247150
Luo et al (2011) Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol 85 8046 PMID: 21680529
Labay et al (2011) Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. Int J High Throughput Screen 2 1 PMID: 26097382
Do you know of a great paper that uses CGK 733 from Tocris? Please let us know.
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for CGK 733
