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Description: DNA topoisomerase inhibitor
Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity: ≥98% (HPLC)
Citations (6)
Literature (2)

Biological Activity for Camptothecin

Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data for Camptothecin

M. Wt 348.36
Formula C20H16N2O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 7689-03-4
PubChem ID 24360
Smiles O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Camptothecin

Solvent Max Conc. mg/mL Max Conc. mM

Preparing Stock Solutions for Camptothecin

The following data is based on the product molecular weight 348.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 57.41 mL 287.06 mL 574.12 mL
0.25 mM 11.48 mL 57.41 mL 114.82 mL
0.5 mM 5.74 mL 28.71 mL 57.41 mL
2.5 mM 1.15 mL 5.74 mL 11.48 mL

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Product Datasheets for Camptothecin

Certificate of Analysis / Product Datasheet
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References for Camptothecin

References are publications that support the biological activity of the product.

Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351 PMID: 2549853

Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873 PMID: 2997227

Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863 PMID: 8449612

Merck Index 12 1783

If you know of a relevant reference for Camptothecin, please let us know.

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Keywords: Camptothecin, Camptothecin supplier, DNA, topoisomerases, inhibitors, inhibits, Isomerases, chemotherapeutics, Topoisomerase, 1100, Tocris Bioscience

6 Citations for Camptothecin

Citations are publications that use Tocris products. Selected citations for Camptothecin include:

Neveu et al (2016) CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica PMID: 27540136

Hellinger et al (2013) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol 151 299 PMID: 24216163

Gründemann et al (2013) Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One 8 e68016 PMID: 23840803

Lamy et al (2013) Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PLoS One 8 e70846 PMID: 23936472

Do you know of a great paper that uses Camptothecin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.