CFM 1571 hydrochloride

Discontinued Product

Unfortunately CFM 1571 hydrochloride (Cat. No. 2586) has been withdrawn from sale for commercial reasons.
Cat.No. 2586 - CFM 1571 hydrochloride | C23H28N4O3.HCl | CAS No. 1215548-30-3
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM).

Compound Libraries

CFM 1571 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 444.95
Formula C23H28N4O3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1215548-30-3
PubChem ID 56972190
InChI Key DFVHCFCSCUCAPD-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(NC(=O)C2=CC(OCCCN(C)C)=NN2CC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 444.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.24 mL 22.47 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Selwood et al (2001) Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J.Med.Chem. 44 78 PMID: 11141091

Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067

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Citations for CFM 1571 hydrochloride

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Cardiovascular

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