CFM 1571 hydrochloride

Discontinued Product

CFM 1571 hydrochloride (Cat. No. 2586) has been withdrawn from sale for commercial reasons.
Cat.No. 2586 - CFM 1571 hydrochloride | C23H28N4O3.HCl | CAS No. 1215548-30-3
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM).

Technical Data

M. Wt 444.95
Formula C23H28N4O3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1215548-30-3
PubChem ID 56972190
InChI Key DFVHCFCSCUCAPD-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(NC(=O)C2=CC(OCCCN(C)C)=NN2CC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Selwood et al (2001) Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J.Med.Chem. 44 78 PMID: 11141091

Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067

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Citations for CFM 1571 hydrochloride

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