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CFM 1571 hydrochloride
Discontinued ProductCFM 1571 hydrochloride (Cat. No. 2586) has been withdrawn from sale for commercial reasons.
Biological Activity for CFM 1571 hydrochloride
Soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM).
Technical Data for CFM 1571 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CFM 1571 hydrochloride
References for CFM 1571 hydrochloride
References are publications that support the biological activity of the product.
Selwood et al (2001) Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J.Med.Chem. 44 78 PMID: 11141091
Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067
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Citations for CFM 1571 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for CFM 1571 hydrochloride.
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Literature in this Area
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