Cetirizine dihydrochloride

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Cat.No. 2577 - Cetirizine dihydrochloride | C21H25ClN2O3.2HCl | CAS No. 83881-52-1
Description: Selective H1 antagonist
Alternative Names: P 071
Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity

Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data

M. Wt 461.81
Formula C21H25ClN2O3.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 83881-52-1
PubChem ID 55182
Smiles Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.18 100
ethanol 4.62 10
water 46.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 461.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.65 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762 PMID: 1981354

Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025 PMID: 1979798

Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158 PMID: 1682275

If you know of a relevant reference for Cetirizine dihydrochloride, please let us know.

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Keywords: Cetirizine dihydrochloride, supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, P, 071, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

3 Citations for Cetirizine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547 PMID: 25714760

Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574 PMID: 25107903

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Do you know of a great paper that uses Cetirizine dihydrochloride from Tocris? If so please let us know.

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