Cetirizine dihydrochloride

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Cat.No. 2577 - Cetirizine dihydrochloride | C21H25ClN2O3.2HCl | CAS No. 83881-52-1
Description: Selective H1 antagonist
Alternative Names: P 071
Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data

M. Wt 461.81
Formula C21H25ClN2O3.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 83881-52-1
PubChem ID 55182
InChI Key PGLIUCLTXOYQMV-UHFFFAOYSA-N
Smiles Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.18 100
DMSO 46.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 461.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.65 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762 PMID: 1981354

Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025 PMID: 1979798

Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158 PMID: 1682275


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Keywords: Cetirizine dihydrochloride, Cetirizine dihydrochloride supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, P, 071, 2577, Tocris Bioscience

3 Citations for Cetirizine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:

Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574 PMID: 25107903

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547 PMID: 25714760

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477


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