CCG 63802

Discontinued Product

CCG 63802 (Cat. No. 4028) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of regulator of G-protein signaling 4 (RGS4) protein
Chemical Name: (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CCG 63802

CCG 63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. Selective amongst RGS proteins, with greatest potency at RGS4. Inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

Technical Data for CCG 63802

M. Wt 450.51
Formula C26H18N4O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 620112-78-9
PubChem ID 6057678
Smiles O=C1C(/C=C(C#N)/C3=NC(C=CC=C4)=C4S3)=C(OC5=CC(C)=CC=C5)N=C2N1C=CC=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CCG 63802

Certificate of Analysis / Product Datasheet
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References for CCG 63802

References are publications that support the biological activity of the product.

Blazer et al (2010) Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol.Pharmacol. 78 524 PMID: 20571077

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Keywords: CCG 63802, CCG 63802 supplier, CCG63802, inhibitors, inhibits, regulator, g-protein, signaling, signalling, RGS, RGS4, G, proteins, Heterotrimeric, G-protein, GTPases, 4028, Tocris Bioscience

1 Citation for CCG 63802

Citations are publications that use Tocris products. Selected citations for CCG 63802 include:

Taccola et al (2016) A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Experimental Neurology 286 1 PMID: 27641322

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Literature in this Area

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