CCG 63802

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Cat.No. 4028 - CCG 63802 | C26H18N4O2S | CAS No. 620112-78-9
Description: Inhibitor of regulator of G-protein signaling 4 (RGS4) protein
Chemical Name: (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

Reversible inhibitor of regulator of G-protein signaling (RGS) proteins. Selective amongst RGS proteins, with greatest potency at RGS4. Inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

Technical Data

M. Wt 450.51
Formula C26H18N4O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 620112-78-9
PubChem ID 6057678
InChI Key VFSVKVQMZDJFQX-NBVRZTHBSA-N
Smiles O=C1C(/C=C(C#N)/C3=NC(C=CC=C4)=C4S3)=C(OC5=CC(C)=CC=C5)N=C2N1C=CC=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.25 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 450.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 44.39 mL 221.97 mL 443.94 mL
0.25 mM 8.88 mL 44.39 mL 88.79 mL
0.5 mM 4.44 mL 22.2 mL 44.39 mL
2.5 mM 0.89 mL 4.44 mL 8.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Blazer et al (2010) Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol.Pharmacol. 78 524 PMID: 20571077


If you know of a relevant reference for CCG 63802, please let us know.

View Related Products by Product Action

View all Heterotrimeric G-protein GTPase Inhibitors

Keywords: CCG 63802, CCG 63802 supplier, CCG63802, inhibitors, inhibits, regulator, g-protein, signaling, signalling, RGS, RGS4, G, proteins, Heterotrimeric, G-protein, GTPases, 4028, Tocris Bioscience

1 Citation for CCG 63802

Citations are publications that use Tocris products. Selected citations for CCG 63802 include:

Taccola et al (2016) A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Experimental Neurology 286 1 PMID: 27641322


Do you know of a great paper that uses CCG 63802 from Tocris? Please let us know.

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Literature in this Area

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