CCG 50014

Pricing Availability   Qty
Description: Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein
Chemical Name: 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for CCG 50014

CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.

Technical Data for CCG 50014

M. Wt 316.35
Formula C16H13FN2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 883050-24-6
PubChem ID 2733079
Smiles FC(C=C3)=CC=C3CN(C(N(C2=CC=C(C)C=C2)S1)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCG 50014

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.64 100

Preparing Stock Solutions for CCG 50014

The following data is based on the product molecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for CCG 50014

References are publications that support the biological activity of the product.

Blazer et al (2011) A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50 3181 PMID: 21329361

Turner et al (2012) Small molecule inhibitors of regulators of G protein signalling (RGS) proteins. ACS Med.Chem.Lett. 3 146 PMID: 22368763

Vashisth et al (2013) Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem.Biol. 8 2778 PMID: 24093330

If you know of a relevant reference for CCG 50014, please let us know.

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Citations for CCG 50014

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