CCG 50014

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Cat.No. 4567 - CCG 50014 | C16H13FN2O2S | CAS No. 883050-24-6
Description: Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein
Chemical Name: 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.

Compound Libraries

CCG 50014 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 316.35
Formula C16H13FN2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 883050-24-6
PubChem ID 2733079
InChI Key QUIIIYITNGOFEI-UHFFFAOYSA-N
Smiles FC(C=C3)=CC=C3CN(C(N(C2=CC=C(C)C=C2)S1)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References

References are publications that support the biological activity of the product.

Blazer et al (2011) A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50 3181 PMID: 21329361

Turner et al (2012) Small molecule inhibitors of regulators of G protein signalling (RGS) proteins. ACS Med.Chem.Lett. 3 146 PMID: 22368763

Vashisth et al (2013) Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem.Biol. 8 2778 PMID: 24093330


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