CC 0651

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Cat.No. 4503 - CC 0651 | C20H21Cl2NO6 | CAS No. 1319207-44-7
Description: Allosteric inhibitor of hCdc34
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.

Technical Data

M. Wt 442.29
Formula C20H21Cl2NO6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1319207-44-7
PubChem ID 53239927
InChI Key NTCBTNCWNRCBGX-YTQUADARSA-N
Smiles ClC1=CC(Cl)=CC(C2=CC=C(C[C@H](NC(COC)=O)[C@@H]([C@H](C(O)=O)O)O)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 44.23 100
DMSO 44.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075 PMID: 21683433

Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156 PMID: 24316736


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Keywords: CC 0651, CC 0651 supplier, CC0651, allosteric, inhibitors, inhibits, hCDC34, ubiquitination, selective, ubl, E2, conjugating, enzymes, Ubiquitin/Ubl, Conjugating, Enzymes, Post-translational, Modifications, 4503, Tocris Bioscience

1 Citation for CC 0651

Citations are publications that use Tocris products. Selected citations for CC 0651 include:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788


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