Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 442.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.26 mL||11.3 mL||22.61 mL|
|5 mM||0.45 mL||2.26 mL||4.52 mL|
|10 mM||0.23 mL||1.13 mL||2.26 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References are publications that support the products' biological activity.
Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075 PMID: 21683433
Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156 PMID: 24316736
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Keywords: CC 0651, supplier, CC0651, allosteric, inhibitors, inhibits, hCDC34, ubiquitination, selective, ubl, E2, conjugating, enzymes, Ubiquitin/Ubl, E2, Conjugating, Enzymes, Post-translational, Modifications, Ubiquitin/Ubl, E2, Conjugating, Enzymes, Tocris Bioscience
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