CC 0651

Pricing Availability Delivery Time Qty
Cat.No. 4503 - CC 0651 | C20H21Cl2NO6 | CAS No. 1319207-44-7
Description: Allosteric inhibitor of hCdc34
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.

Technical Data

M. Wt 442.29
Formula C20H21Cl2NO6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1319207-44-7
PubChem ID 53239927
InChI Key NTCBTNCWNRCBGX-YTQUADARSA-N
Smiles ClC1=CC(Cl)=CC(C2=CC=C(C[C@H](NC(COC)=O)[C@@H]([C@H](C(O)=O)O)O)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 44.23 100
DMSO 44.23 100
ethanol 22.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 442.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075 PMID: 21683433

Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156 PMID: 24316736


If you know of a relevant reference for CC 0651, please let us know.

View Related Products by Product Action

View all Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

Keywords: CC0651 allosteric inhibitors inhibits hCDC34 ubiquitination selective ubl E2 conjugating enzymes Ubiquitin/Ubl E2 Conjugating Enzymes

Citations for CC 0651

Citations are publications that use Tocris products.

Currently there are no citations for CC 0651. Do you know of a great paper that uses CC 0651 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for CC 0651

Protocols

TODO: Add Protocols