CC 0651
Biological Activity
Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
Technical Data
| M. Wt | 442.29 |
| Formula | C20H21Cl2NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1319207-44-7 |
| PubChem ID | 53239927 |
| InChI Key | NTCBTNCWNRCBGX-YTQUADARSA-N |
| Smiles | ClC1=CC(Cl)=CC(C2=CC=C(C[C@H](NC(COC)=O)[C@@H]([C@H](C(O)=O)O)O)C=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 44.23 | 100 | |
| DMSO | 44.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 442.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.3 mL | 22.61 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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References
References are publications that support the biological activity of the product.
Ceccarelli et al (2011) An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell 145 1075 PMID: 21683433
Huang et al (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat.Chem.Biol. 10 156 PMID: 24316736
If you know of a relevant reference for CC 0651, please let us know.
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Keywords: CC 0651, CC 0651 supplier, CC0651, allosteric, inhibitors, inhibits, hCDC34, ubiquitination, selective, ubl, E2, conjugating, enzymes, Ubiquitin/Ubl, Conjugating, Enzymes, Post-translational, Modifications, 4503, Tocris Bioscience
1 Citation for CC 0651
Citations are publications that use Tocris products. Selected citations for CC 0651 include:
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Do you know of a great paper that uses CC 0651 from Tocris? Please let us know.
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