Catestatin

Pricing Availability Delivery Time Qty
Cat.No. 2722 - Catestatin | Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Leu-Gln-Leu | CAS No. 142211-96-9
Description: Non-competitive nicotinic cholinergic antagonist
Alternative Names: Chromogranin A344-364
Datasheet
Citations

Biological Activity

Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.

Technical Data

M. Wt 2425.84
Formula C107H173N37O26S
Sequence RSMRLSFRARGYGFRGPGLQL
Storage Store at -20°C
CAS Number 142211-96-9
PubChem ID 16143960
InChI Key HCEYIDADOJWYIM-DIWOTYQXSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2425.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.41 mL 2.06 mL 4.12 mL
5 mM 0.08 mL 0.41 mL 0.82 mL
10 mM 0.04 mL 0.21 mL 0.41 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623 PMID: 9294131

Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525 PMID: 11043569

Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29 PMID:


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Keywords: Non-competitive nicotinic cholinergic antagonists Acetylcholine Receptors Non-Selective Subtypes nAChR Chromogranin A344-364 A344364 Chromogranin A344-364 Nicotinic Receptors (Non-selective)

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