Highly selective H3 receptor antagonist (Ki values are 0.30, 365 and 3621 μM for H3, H2 and H1 receptors respectively). Acts as a natural antioxidant with hydroxyl radical scavenging and lipid peroxidase activities.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 410.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.44 mL||12.19 mL||24.37 mL|
|5 mM||0.49 mL||2.44 mL||4.87 mL|
|10 mM||0.24 mL||1.22 mL||2.44 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Babizhayev et al (1994) L-Carnosine (β-alanyl-L-histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Biochem.J. 304 509 PMID: 7998987
Chen et al (2004) Pharmacological effects of carcinine on histaminergic neurons in the brain. Br.J.Pharmacol. 143 573 PMID: 15466447
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Keywords: Highly selective H3 antagonists Histamine Receptors histaminergic Histamine H3 Receptors
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