Carcinine ditrifluoroacetate

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Cat.No. 2211 - Carcinine ditrifluoroacetate | C8H14N4O.2CF3CO2H | CAS No. 56897-53-1
Description: Highly selective H3 antagonist
Chemical Name: 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide ditrifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly selective H3 receptor antagonist (Ki values are 0.30, 365 and 3621 μM for H3, H2 and H1 receptors respectively). Acts as a natural antioxidant with hydroxyl radical scavenging and lipid peroxidase activities.

Technical Data

M. Wt 410.27
Formula C8H14N4O.2CF3CO2H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 56897-53-1
PubChem ID 121513843
InChI Key YLYHHFINLFZZKK-UHFFFAOYSA-N
Smiles NCCC(NCCC1=CN=CN1)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.03 100
water 41.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 410.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.19 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Babizhayev et al (1994) L-Carnosine (β-alanyl-L-histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Biochem.J. 304 509 PMID: 7998987

Chen et al (2004) Pharmacological effects of carcinine on histaminergic neurons in the brain. Br.J.Pharmacol. 143 573 PMID: 15466447


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