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Aldehyde oxidase (AO) substrate. Exhibits activities as a phosphodiesterase inhibitor; produces concentration-dependent positive inotropic responses in isolated right atria.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 552.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.81 mL||9.05 mL||18.1 mL|
|5 mM||0.36 mL||1.81 mL||3.62 mL|
|10 mM||0.18 mL||0.9 mL||1.81 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Hutzler et al (2011) Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab.Dispos. 40 267 PMID: 22031625
Shahid and Rodger et al (1989) Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br.J.Pharmacol. 98 291 PMID: 2478244
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Keywords: Carbazeran citrate, Carbazeran citrate supplier, Aldehyde, oxidases, AO, substrates, phosphodiesterase, inhibitors, inhibits, PDE, inotropic, Other, Oxygenases/Oxidases, Phosphodiesterases, 4420, Tocris Bioscience
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