Carbazeran citrate

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Cat.No. 4420 - Carbazeran citrate | C18H24N4O4.C6H8O7 | CAS No. 153473-94-0
Description: Aldehyde oxidase substrate; PDE inhibitor
Chemical Name: Ethyl 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl carbamate citrate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Aldehyde oxidase (AO) substrate. Exhibits activities as a phosphodiesterase inhibitor; produces concentration-dependent positive inotropic responses in isolated right atria.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 552.53
Formula C18H24N4O4.C6H8O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 153473-94-0
PubChem ID 90488940
InChI Key QKMRPDVEKBYWPF-UHFFFAOYSA-N
Smiles O=C(NCC)OC(CC3)CCN3C2=NN=CC1=CC(OC)=C(OC)C=C12.OC(CC(C(O)=O)(O)CC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.25 100
ethanol 5.53 10
water 27.63 50

Preparing Stock Solutions

The following data is based on the product molecular weight 552.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.05 mL 18.1 mL
5 mM 0.36 mL 1.81 mL 3.62 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hutzler et al (2011) Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab.Dispos. 40 267 PMID: 22031625

Shahid and Rodger et al (1989) Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br.J.Pharmacol. 98 291 PMID: 2478244


If you know of a relevant reference for Carbazeran citrate, please let us know.

Keywords: Aldehyde oxidases AO substrates phosphodiesterase inhibitors inhibits PDE inotropic Other Oxygenases/Oxidases

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