Carbazeran citrate

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Cat.No. 4420 - Carbazeran citrate | C18H24N4O4.C6H8O7 | CAS No. 153473-94-0
Description: Aldehyde oxidase substrate; PDE inhibitor
Chemical Name: Ethyl 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl carbamate citrate
Purity: ≥98% (HPLC)

Biological Activity for Carbazeran citrate

Carbazeran citrate is an aldehyde oxidase (AO) substrate. Exhibits activities as a phosphodiesterase inhibitor; produces concentration-dependent positive inotropic responses in isolated right atria.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Carbazeran citrate

M. Wt 552.53
Formula C18H24N4O4.C6H8O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 153473-94-0
PubChem ID 90488940
Smiles O=C(NCC)OC(CC3)CCN3C2=NN=CC1=CC(OC)=C(OC)C=C12.OC(CC(C(O)=O)(O)CC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Carbazeran citrate

Solvent Max Conc. mg/mL Max Conc. mM
water 27.63 50
DMSO 55.25 100

Preparing Stock Solutions for Carbazeran citrate

The following data is based on the product molecular weight 552.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.05 mL 18.1 mL
5 mM 0.36 mL 1.81 mL 3.62 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets for Carbazeran citrate

References for Carbazeran citrate

References are publications that support the biological activity of the product.

Hutzler et al (2011) Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab.Dispos. 40 267 PMID: 22031625

Shahid and Rodger et al (1989) Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br.J.Pharmacol. 98 291 PMID: 2478244

If you know of a relevant reference for Carbazeran citrate, please let us know.

Keywords: Carbazeran citrate, Carbazeran citrate supplier, Aldehyde, oxidases, AO, substrates, phosphodiesterase, inhibitors, inhibits, PDE, inotropic, Other, Oxygenases/Oxidases, Phosphodiesterases, 4420, Tocris Bioscience

Citations for Carbazeran citrate

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