Capzimin dimer

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 6781 - Capzimin dimer | C30H24N6O2S4 | CAS No. 2084868-04-0
Description: Selective proteasome inhibitor
Chemical Name: 8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Capzimin dimer

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.

Technical Data for Capzimin dimer

M. Wt 628.8
Formula C30H24N6O2S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2084868-04-0
PubChem ID 126599606
InChI Key RNEOHKZPZKEZCQ-UHFFFAOYSA-N
Smiles O=C(C1=CC2=C(C(SSC3=CC=CC4=C3N=CC(C(NCCC5=NC=CS5)=O)=C4)=CC=C2)N=C1)NCCC6=NC=CS6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Capzimin dimer

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.88 100

Preparing Stock Solutions for Capzimin dimer

The following data is based on the product molecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.8 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Capzimin dimer

References for Capzimin dimer

References are publications that support the biological activity of the product.

Perez et al (2017) Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 60 1343 PMID: 28191850

Li et al (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 13 486 PMID: 28244987


If you know of a relevant reference for Capzimin dimer, please let us know.

View Related Products by Product Action

View all Proteasome Inhibitors

Keywords: Capzimin dimer, Capzimin dimer supplier, Selective, proteasome, inhibitor, inhibitors, inhibits, inhibit, isopeptidase, Rpn11, Proteasome, 6781, Tocris Bioscience

Citations for Capzimin dimer

Citations are publications that use Tocris products.

Currently there are no citations for Capzimin dimer. Do you know of a great paper that uses Capzimin dimer from Tocris? Please let us know.

Reviews for Capzimin dimer

There are currently no reviews for this product. Be the first to review Capzimin dimer and earn rewards!

Have you used Capzimin dimer?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration Product Guide

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Custom Degrader Services
  • Ubiquitin-Proteasome System Proteins and Assays
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia