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Biological Activity for Capzimin dimer
Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.
Technical Data for Capzimin dimer
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Capzimin dimer
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Capzimin dimer
The following data is based on the product molecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.59 mL||7.95 mL||15.9 mL|
|5 mM||0.32 mL||1.59 mL||3.18 mL|
|10 mM||0.16 mL||0.8 mL||1.59 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References for Capzimin dimer
References are publications that support the biological activity of the product.
Perez et al (2017) Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 60 1343 PMID: 28191850
Li et al (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 13 486 PMID: 28244987
If you know of a relevant reference for Capzimin dimer, please let us know.
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Keywords: Capzimin dimer, Capzimin dimer supplier, Selective, proteasome, inhibitor, inhibitors, inhibits, inhibit, isopeptidase, Rpn11, Proteasome, 6781, Tocris Bioscience
Citations for Capzimin dimer
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Literature in this Area
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia