Captopril

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Cat.No. 4455 - Captopril | C9H15NO3S | CAS No. 62571-86-2
Description: ACE inhibitor; also inhibits LTA4 hydrolase
Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase.

Technical Data

M. Wt 217.29
Formula C9H15NO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 62571-86-2
PubChem ID 44093
InChI Key FAKRSMQSSFJEIM-RQJHMYQMSA-N
Smiles O=C([C@H](C)CS)N1[C@H](C(O)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.73 100
ethanol 21.73 100
water 21.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.01 mL 46.02 mL
5 mM 0.92 mL 4.6 mL 9.2 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (1996) Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin.Exp.Hypertens. 18 201 PMID: 8869001

Orning et al (1991) Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. J.Biol.Chem. 266 16507 PMID: 1885582

Fujita and Yoshikawa (1999) LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44 123 PMID: 10604535


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Keywords: Captopril, supplier, ACE, inhibitors, angiotensin-converting, enzyme, antihypertensives, LTA4, reversible, inhibits, peptidyl, dipeptidase, A, carboxycathepsin, Angiotensin-Converting, Enzyme, Aminopeptidases, LTA4, Hydrolase, Angiotensin-Converting, Enzyme, Tocris Bioscience

Citations for Captopril

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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