Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.6 mL||23.01 mL||46.02 mL|
|5 mM||0.92 mL||4.6 mL||9.2 mL|
|10 mM||0.46 mL||2.3 mL||4.6 mL|
|50 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the products' biological activity.
Zhang et al (1996) Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin.Exp.Hypertens. 18 201 PMID: 8869001
Orning et al (1991) Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. J.Biol.Chem. 266 16507 PMID: 1885582
Fujita and Yoshikawa (1999) LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44 123 PMID: 10604535
If you know of a relevant reference for Captopril, please let us know.
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Keywords: Captopril, supplier, ACE, inhibitors, angiotensin-converting, enzyme, antihypertensives, LTA4, reversible, inhibits, peptidyl, dipeptidase, A, carboxycathepsin, Angiotensin-Converting, Enzyme, Aminopeptidases, LTA4, Hydrolase, Angiotensin-Converting, Enzyme, Tocris Bioscience
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