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Submit ReviewCaptopril
Description: ACE inhibitor; also inhibits LTA4 hydrolase
Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Purity: ≥98% (HPLC)
Biological Activity
Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Identified as targeting human host proteins that interact with SARS-CoV-2.
Technical Data
| M. Wt | 217.29 |
| Formula | C9H15NO3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 62571-86-2 |
| PubChem ID | 44093 |
| InChI Key | FAKRSMQSSFJEIM-RQJHMYQMSA-N |
| Smiles | O=C([C@H](C)CS)N1[C@H](C(O)=O)CCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.73 | 100 | |
| DMSO | 21.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.6 mL | 23.01 mL | 46.02 mL |
| 5 mM | 0.92 mL | 4.6 mL | 9.2 mL |
| 10 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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References
References are publications that support the biological activity of the product.
Zhang et al (1996) Effects of early capt. treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin.Exp.Hypertens. 18 201 PMID: 8869001
Orning et al (1991) Inhibition of leukotriene A4 hydrolase/aminopeptidase by capt. J.Biol.Chem. 266 16507 PMID: 1885582
Fujita and Yoshikawa (1999) LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44 123 PMID: 10604535
Gordon et al A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature PMID: 32353859
If you know of a relevant reference for Captopril, please let us know.
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Keywords: Captopril, Captopril supplier, ACE, inhibitors, angiotensin-converting, enzyme, antihypertensives, LTA4, reversible, inhibits, peptidyl, dipeptidase, A, carboxycathepsin, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Angiotensin-Converting, Enzyme, Aminopeptidases, Hydrolase, 4455, Tocris Bioscience
1 Citation for Captopril
Citations are publications that use Tocris products. Selected citations for Captopril include:
Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082
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Literature in this Area
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Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure