Discontinued Product

Cantharidin (Cat. No. 1548) has been withdrawn from sale for commercial reasons.
Description: Protein phosphatase 1 and 2A inhibitor
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Citations (5)

Biological Activity for Cantharidin

Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.

Technical Data for Cantharidin

M. Wt 196.2
Formula C10H12O4
Storage Store at RT
CAS Number 56-25-7
PubChem ID 5944
Smiles O=C(O2)[C@]1(C)[C@H](O3)CC[C@H]3[C@@](C)1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Cantharidin

Certificate of Analysis / Product Datasheet
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References for Cantharidin

References are publications that support the biological activity of the product.

Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95 PMID: 7839375

Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283 PMID: 8397101

Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480 PMID: 10336542

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Keywords: Cantharidin, Cantharidin supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, 1548, Tocris Bioscience

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