Cantharidin

Pricing Availability Delivery Time Qty
Cat.No. 1548 - Cantharidin | C10H12O4 | CAS No. 56-25-7
Description: Protein phosphatase 1 and 2A inhibitor
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Datasheet
Citations (2)
Literature

Biological Activity

Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.

Technical Data

M. Wt 196.2
Formula C10H12O4
Storage Store at RT
CAS Number 56-25-7
PubChem ID 5944
InChI Key DHZBEENLJMYSHQ-XCVPVQRUSA-N
Smiles O=C(O2)[C@]1(C)[C@H](O3)CC[C@H]3[C@@](C)1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.62 100
ethanol 4.91 25

Preparing Stock Solutions

The following data is based on the product molecular weight 196.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.1 mL 25.48 mL 50.97 mL
5 mM 1.02 mL 5.1 mL 10.19 mL
10 mM 0.51 mL 2.55 mL 5.1 mL
50 mM 0.1 mL 0.51 mL 1.02 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95 PMID: 7839375

Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283 PMID: 8397101

Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480 PMID: 10336542


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Keywords: Protein phosphatase 1 2A inhibitors inhibits Calcineurin Ser/Thr Phosphatases PP1 PP2A Protein Ser/Thr Phosphatases

2 Citations for Cantharidin

Citations are publications that use Tocris products. Selected citations for Cantharidin include:

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Biol Chem 2 PMID: 26465004

Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Cell Death Dis 289 14600 PMID: 24706758


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Literature in this Area

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Cancer Research Product Guide

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Pathways for Cantharidin

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