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Submit ReviewCantharidin
Description: Protein phosphatase 1 and 2A inhibitor
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Biological Activity for Cantharidin
Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.
Technical Data for Cantharidin
| M. Wt | 196.2 |
| Formula | C10H12O4 |
| Storage | Store at RT |
| CAS Number | 56-25-7 |
| PubChem ID | 5944 |
| InChI Key | DHZBEENLJMYSHQ-XCVPVQRUSA-N |
| Smiles | O=C(O2)[C@]1(C)[C@H](O3)CC[C@H]3[C@@](C)1C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cantharidin
References for Cantharidin
References are publications that support the biological activity of the product.
Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95 PMID: 7839375
Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283 PMID: 8397101
Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480 PMID: 10336542
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Keywords: Cantharidin, Cantharidin supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, 1548, Tocris Bioscience
5 Citations for Cantharidin
Citations are publications that use Tocris products. Selected citations for Cantharidin include:
Egbert et al (2014) Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. Development 141 3594 PMID: 25183874
Shuhaibar et al (2017) Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. Elife 6 PMID: 29199951
Lang et al (2019) Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell 24 93 PMID: 30503143
Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Cell Death Dis 289 14600 PMID: 24706758
Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Biol Chem 2 PMID: 26465004
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