Cambinol

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Cat.No. 7137 - Cambinol | C21H16N2O2S | CAS No. 14513-15-6
Description: nSMase2 inhibitor
Chemical Name: 2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Cambinol

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 μM; IC50 ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

Technical Data for Cambinol

M. Wt 360.43
Formula C21H16N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 14513-15-6
PubChem ID 3246390
InChI Key RVNSQVIUFZVNAU-UHFFFAOYSA-N
Smiles OC1=C(C2=CC=CC=C2C=C1)CC3=C(C4=CC=CC=C4)NC(NC3=O)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cambinol

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100

Preparing Stock Solutions for Cambinol

The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for Cambinol

References are publications that support the biological activity of the product.

Figuera-Losada et al (2015) Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 10 e0124481 PMID: 26010541

Stepanek et al (2019) Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur.J.Med.Chem. 170 276 PMID: 30921693

Sackmann et al (2019) Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia. Front.Mol.Neurosci. 12 200 PMID: 31555088

Bilousova (2018) Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem.Biophys.Res.Commun. 499 751 PMID: 29604274

Heltweg et al (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66 4368 PMID: 16618762


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Keywords: Cambinol, Cambinol supplier, neutral, sphingomyelinase, 2, nSMase2, inhibition, inhibitors, inhibits, Sphingomyelin, SMase, brain, penetrant, SIRT1, SIRT2, antitumor, tau, Other, Hydrolases, Class, III, HDACs, (Sirtuins), 7137, Tocris Bioscience

Citations for Cambinol

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