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Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 μM; IC50 ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.74 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References are publications that support the biological activity of the product.
Figuera-Losada et al (2015) Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 10 e0124481 PMID: 26010541
Stepanek et al (2019) Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur.J.Med.Chem. 170 276 PMID: 30921693
Sackmann et al (2019) Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia. Front.Mol.Neurosci. 12 200 PMID: 31555088
Bilousova (2018) Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem.Biophys.Res.Commun. 499 751 PMID: 29604274
Heltweg et al (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66 4368 PMID: 16618762
If you know of a relevant reference for Cambinol, please let us know.
Keywords: Cambinol, Cambinol supplier, neutral, sphingomyelinase, 2, nSMase2, inhibition, inhibitors, inhibits, Sphingomyelin, SMase, brain, penetrant, SIRT1, SIRT2, antitumor, tau, Other, Hydrolases, Class, III, HDACs, (Sirtuins), 7137, Tocris Bioscience
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