Calcifediol

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Cat.No. 4036 - Calcifediol | C27H44O2 | CAS No. 19356-17-3
Description: Prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D
Alternative Names: 25-Hydroxyvitamin D3, Calcidiol
Chemical Name: (εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D. Suppresses PTH synthesis and secretion in bovine parathyroid cells (ED50 = 2 nM).

Technical Data

M. Wt 400.64
Formula C27H44O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 19356-17-3
PubChem ID 5283731
InChI Key JWUBBDSIWDLEOM-DTOXIADCSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)CC1)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO and in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 400.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.48 mL 24.96 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ritter et al (2006) 25-hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 70 654 PMID: 16807549

Rowling et al (2006) Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J.Nutr. 136 2754 PMID: 17056796

Fedirko et al (2010) Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am.J.Epidemiol. 172 489 PMID: 20650953


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View Related Products by Target

Keywords: major circulating forms vitamin D cholecalciferol 25-HydroxyvitaminD3 calcitriol 1,25-DihydroxyvitaminD3 25-Hydroxyvitamin D3 Calcidiol Vitamin D Receptors

1 Citation for Calcifediol

Citations are publications that use Tocris products. Selected citations for Calcifediol include:

Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Biochim Biophys Acta 77 73 PMID: 25237378


Do you know of a great paper that uses Calcifediol from Tocris? If so please let us know.

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