Discontinued Product

Calcifediol (Cat. No. 4036) has been withdrawn from sale for commercial reasons.
Description: Prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D
Alternative Names: 25-Hydroxyvitamin D3,Calcidiol
Chemical Name: (εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for Calcifediol

Calcifediol is a prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D. Suppresses PTH synthesis and secretion in bovine parathyroid cells (ED50 = 2 nM).

Technical Data for Calcifediol

M. Wt 400.64
Formula C27H44O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 19356-17-3
PubChem ID 5283731
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)CC1)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Calcifediol

Certificate of Analysis / Product Datasheet
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References for Calcifediol

References are publications that support the biological activity of the product.

Ritter et al (2006) 25-hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 70 654 PMID: 16807549

Rowling et al (2006) Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J.Nutr. 136 2754 PMID: 17056796

Fedirko et al (2010) Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am.J.Epidemiol. 172 489 PMID: 20650953

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Keywords: Calcifediol, Calcifediol supplier, major, circulating, forms, vitamin, D, cholecalciferol, 25-HydroxyvitaminD3, calcitriol, 1,25-DihydroxyvitaminD3, 25-Hydroxyvitamin, D3, Calcidiol, Vitamin, Receptors, 4036, Tocris Bioscience

2 Citations for Calcifediol

Citations are publications that use Tocris products. Selected citations for Calcifediol include:

Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Biochim Biophys Acta 77 73 PMID: 25237378

Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687

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