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Submit ReviewCalcifediol
Description: Prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D
Alternative Names: 25-Hydroxyvitamin D3, Calcidiol
Chemical Name: (εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol
Purity: ≥98% (HPLC)
Biological Activity for Calcifediol
Calcifediol is a prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D. Suppresses PTH synthesis and secretion in bovine parathyroid cells (ED50 = 2 nM).
Technical Data for Calcifediol
| M. Wt | 400.64 |
| Formula | C27H44O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 19356-17-3 |
| PubChem ID | 5283731 |
| InChI Key | JWUBBDSIWDLEOM-DTOXIADCSA-N |
| Smiles | C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)CC1)\C1=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Calcifediol
| Solubility | Soluble in DMSO and in ethanol |
Product Datasheets for Calcifediol
References for Calcifediol
References are publications that support the biological activity of the product.
Ritter et al (2006) 25-hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 70 654 PMID: 16807549
Rowling et al (2006) Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J.Nutr. 136 2754 PMID: 17056796
Fedirko et al (2010) Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am.J.Epidemiol. 172 489 PMID: 20650953
If you know of a relevant reference for Calcifediol, please let us know.
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Keywords: Calcifediol, Calcifediol supplier, major, circulating, forms, vitamin, D, cholecalciferol, 25-HydroxyvitaminD3, calcitriol, 1,25-DihydroxyvitaminD3, 25-Hydroxyvitamin, D3, Calcidiol, Vitamin, Receptors, 4036, Tocris Bioscience
1 Citation for Calcifediol
Citations are publications that use Tocris products. Selected citations for Calcifediol include:
Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Biochim Biophys Acta 77 73 PMID: 25237378
Do you know of a great paper that uses Calcifediol from Tocris? Please let us know.
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