Discontinued Product

BzF (Cat. No. 6786) has been withdrawn from sale for commercial reasons.
Description: Photoreactive unnatural amino acid; photo-crosslinker
Chemical Name: 4-Benzoyl-L-phenylalanine
Purity: ≥98% (HPLC)

Biological Activity for BzF

BzF is a photoreactive unnatural amino acid. Acts as photo cross-linking probe when incorporated into proteins, including ion channels, transporters and GPCRs. When exposed to UV light it forms a covalent cross-link with a C-H bond-containing group, enabling selective and potent UV-driven photoinactivation of protein function. Has been used to study protein-protein and protein-ligand interactions.

Technical Data for BzF

M. Wt 269.3
Formula C16H15NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 104504-45-2
PubChem ID 7020128
Smiles N[C@H](C(O)=O)CC1=CC=C(C(C2=CC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BzF

References are publications that support the biological activity of the product.

Ye et al (2008) Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis. J.Biol.Chem. 283 1525 PMID: 17993461

Klippenstein et al (2018) Probing ion channel structure and function using light-sensitive amino acids. Trends Biochem.Sci. 43 436 PMID: 29650383

Klippenstein et al (2014) Photoinactivation of glutamate receptors by genetically encoded unnatural amino acids. J.Neurosci. 34 980 PMID: 24431456

Keywords: BzF, BzF supplier, photoreactive, unnatural, amino, acid, UAA, photoactivates, covalent, cross-linking, probe, protein-protein, interaction, Biochemicals, and, Molecular, Biology, Unnatural, Amino, Acids, Photoactivatable, probes, 6786, Tocris Bioscience

Citations for BzF

Citations are publications that use Tocris products.

Currently there are no citations for BzF.

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