BYK 49187

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Cat.No. 3735 - BYK 49187 | C19H21N5O | CAS No. 163120-31-8
Description: PARP-1 and PARP-2 inhibitor
Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity

PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.

Technical Data

M. Wt 335.4
Formula C19H21N5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 163120-31-8
PubChem ID 15285131
Smiles O=C2CCN3C1=C(N=C3N4CCC(C5=C(C)N=CN5)CC4)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.35 10
ethanol 16.77 50

Preparing Stock Solutions

The following data is based on the product molecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.96 mL 29.82 mL 59.63 mL
2.5 mM 1.19 mL 5.96 mL 11.93 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
25 mM 0.12 mL 0.6 mL 1.19 mL

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References are publications that support the biological activity of the product.

Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587 PMID: 18809672

Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049 PMID: 21417348

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