BYK 191023 dihydrochloride

Discontinued Product

BYK 191023 dihydrochloride (Cat. No. 2866) has been withdrawn from sale for commercial reasons.
Cat.No. 2866 - BYK 191023 dihydrochloride | C14H14N4O.2HCl | CAS No. 1216722-25-6
Description: Potent and selective inhibitor of iNOS
Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for BYK 191023 dihydrochloride

BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.

Licensing Information

Sold with the permission of Nycomed

Technical Data for BYK 191023 dihydrochloride

M. Wt 327.21
Formula C14H14N4O.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1216722-25-6
PubChem ID 56972216
Smiles COC1=CC(CCC2=NC(N=CC=C3)=C3N2)=NC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BYK 191023 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for BYK 191023 dihydrochloride

References are publications that support the biological activity of the product.

Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181 PMID: 16368897

Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328

Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244

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Citations for BYK 191023 dihydrochloride

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