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Submit ReviewBX 430
Description: Selective P2X4 allosteric antagonist
Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
Purity: ≥99% (HPLC)
Biological Activity for BX 430
BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.
Technical Data for BX 430
| M. Wt | 413.11 |
| Formula | C15H15Br2N3O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 688309-70-8 |
| PubChem ID | 2810999 |
| InChI Key | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BX 430
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.31 | 100 | |
| ethanol | 41.31 | 100 |
Preparing Stock Solutions for BX 430
The following data is based on the product molecular weight 413.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.1 mL | 24.21 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for BX 430
References for BX 430
References are publications that support the biological activity of the product.
Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606 PMID: 25597706
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Keywords: BX 430, BX 430 supplier, BX430, selective, allosteric, noncompetitive, antagonists, antaognism, purinergic, receptors, purinoceptors, P2X4, P2X, Receptors, 5545, Tocris Bioscience
2 Citations for BX 430
Citations are publications that use Tocris products. Selected citations for BX 430 include:
Belinda L et al (2020) Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol 177 2812-2829 PMID: 32017039
Datta et al (2019) HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. Front Cell Neurosci 13 329 PMID: 31379513
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.