BX 430

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Cat.No. 5545 - BX 430 | C15H15Br2N3O | CAS No. 688309-70-8
Description: Selective P2X4 allosteric antagonist
Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

Technical Data

M. Wt 413.11
Formula C15H15Br2N3O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 688309-70-8
PubChem ID 2810999
InChI Key JFNKIJKRXKPQCC-UHFFFAOYSA-N
Smiles CC(C)C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.31 100
ethanol 41.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 413.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.1 mL 24.21 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606 PMID: 25597706


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