BWX 46

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Cat.No. 2035 - BWX 46 | Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 (Disulfide bridge: 5-5*) | CAS No. 172997-92-1
Description: Highly selective NPY Y5 agonist
Alternative Names: Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}

Biological Activity

Potent and highly selective NPY Y5 receptor agonist (Ki values are 0.85, 42, 3015 and 245 nM at Y5, Y1, Y2 and Y4 receptors respectively). Stimulates food intake gradually following intrahypothalamic administration in rats.

Technical Data

M. Wt 2597.09
Formula C116H186N36O28S2

(Modifications: X = Nva, Tyr-10 = C-terminal amide, X* = Nva, Tyr-10* = C-terminal amide, Disulfide bridge between 5 - 5*)

Storage Desiccate at -20°C
CAS Number 172997-92-1
PubChem ID 16142371
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N[H])CC1=CC=C(O)C=C1)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2597.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.39 mL 1.93 mL 3.85 mL
5 mM 0.08 mL 0.39 mL 0.77 mL
10 mM 0.04 mL 0.19 mL 0.39 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Balasubramaniam et al (2002) Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides 23 1485 PMID: 12182951

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Keywords: BWX 46, supplier, selective, Y5, agonists, Neuropeptide, Y, Receptors, NPY, BWX46, neuropeptides, Bis(31/31')[Cys31,, Nva34]NPY(27-36)-NH2}, NPY, Receptors, NPY, Receptors, Tocris Bioscience

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