BWX 46

Discontinued Product

BWX 46 (Cat. No. 2035) has been withdrawn from sale for commercial reasons.
Cat.No. 2035 - BWX 46 | Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 (Disulfide bridge: 5-5*) | CAS No. 172997-92-1
Description: Highly selective NPY Y5 agonist
Alternative Names: Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and highly selective NPY Y5 receptor agonist (Ki values are 0.85, 42, 3015 and 245 nM at Y5, Y1, Y2 and Y4 receptors respectively). Stimulates food intake gradually following intrahypothalamic administration in rats.

Technical Data

M. Wt 2597.09
Formula C116H186N36O28S2
Sequence YINLCTRXRY YINLCTRXRY*

(Modifications: X = Nva, Tyr-10 = C-terminal amide, X* = Nva, Tyr-10* = C-terminal amide, Disulfide bridge between 5 - 5*)

Storage Desiccate at -20°C
CAS Number 172997-92-1
PubChem ID 16142371
InChI Key NCCWKDKNIQUYAI-JULUKTQUSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N[H])CC1=CC=C(O)C=C1)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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References

References are publications that support the biological activity of the product.

Balasubramaniam et al (2002) Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides 23 1485 PMID: 12182951

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Keywords: BWX 46, BWX 46 supplier, selective, Y5, agonists, Neuropeptide, Y, Receptors, NPY, BWX46, neuropeptides, Bis(31/31')[Cys31,, Nva34]NPY(27-36)-NH2}, 2035, Tocris Bioscience

Citations for BWX 46

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