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Potent and selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 316.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.03 mM||105.38 mL||526.88 mL||1053.75 mL|
|0.15 mM||21.08 mL||105.38 mL||210.75 mL|
|0.3 mM||10.54 mL||52.69 mL||105.38 mL|
|1.5 mM||2.11 mL||10.54 mL||21.08 mL|
References are publications that support the biological activity of the product.
Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063
Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758
Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540
If you know of a relevant reference for BW-B 70C, please let us know.
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Keywords: BW-B 70C, BW-B 70C supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, 1304, Tocris Bioscience
1 Citation for BW-B 70C
Citations are publications that use Tocris products. Selected citations for BW-B 70C include:
Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978
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