BW-B 70C

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Cat.No. 1304 - BW-B 70C | C17H17FN2O3 | CAS No. 134470-38-5
Description: 5-Lipoxygenase inhibitor
Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BW-B 70C

BW-B 70C is a potent and selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.

Technical Data for BW-B 70C

M. Wt 316.33
Formula C17H17FN2O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 134470-38-5
PubChem ID 5353454
Smiles CC(\C=C\C1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BW-B 70C

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 3

Preparing Stock Solutions for BW-B 70C

The following data is based on the product molecular weight 316.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.03 mM 105.38 mL 526.88 mL 1053.75 mL
0.15 mM 21.08 mL 105.38 mL 210.75 mL
0.3 mM 10.54 mL 52.69 mL 105.38 mL
1.5 mM 2.11 mL 10.54 mL 21.08 mL

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Product Datasheets for BW-B 70C

Certificate of Analysis / Product Datasheet
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References for BW-B 70C

References are publications that support the biological activity of the product.

Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758

Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540

If you know of a relevant reference for BW-B 70C, please let us know.

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Keywords: BW-B 70C, BW-B 70C supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, 1304, Tocris Bioscience

1 Citation for BW-B 70C

Citations are publications that use Tocris products. Selected citations for BW-B 70C include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978

Do you know of a great paper that uses BW-B 70C from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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