BW-B 70C

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Cat.No. 1304 - BW-B 70C | C17H17FN2O3 | CAS No. 134470-38-5
Description: 5-Lipoxygenase inhibitor
Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.

Technical Data

M. Wt 316.33
Formula C17H17FN2O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 134470-38-5
PubChem ID 5353454
InChI Key UAIYNMRLUHHRMF-AATRIKPKSA-N
Smiles CC(\C=C\C1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 3 mM in ethanol and to 3 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 316.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758

Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540


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Keywords: 5-lipoxygenase inhibitors oxygenases inhibits oxidases BWB70C 5-LOX Lipoxygenase

1 Citation for BW-B 70C

Citations are publications that use Tocris products. Selected citations for BW-B 70C include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978


Do you know of a great paper that uses BW-B 70C from Tocris? If so please let us know.

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Literature in this Area

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