BW-B 70C

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Cat.No. 1304 - BW-B 70C | C17H17FN2O3 | CAS No. 134470-38-5
Description: 5-Lipoxygenase inhibitor
Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Potent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.

Technical Data

M. Wt 316.33
Formula C17H17FN2O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 134470-38-5
PubChem ID 5353454
Smiles CC(\C=C\C1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 3 mM in ethanol and to 3 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 316.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758

Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540

If you know of a relevant reference for BW-B 70C, please let us know.

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Keywords: BW-B 70C, supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, Lipoxygenase, Tocris Bioscience

1 Citation for BW-B 70C

Citations are publications that use Tocris products. Selected citations for BW-B 70C include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978

Do you know of a great paper that uses BW-B 70C from Tocris? If so please let us know.

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