BW 723C86 hydrochloride

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Cat.No. 1059 - BW 723C86 hydrochloride | C16H18N2OS.HCl | CAS No. 160521-72-2
Description: 5-HT2B agonist
Chemical Name: α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews (1)
Literature (3)

Biological Activity

Selective 5-HT2B receptor agonist.

Technical Data

M. Wt 322.85
Formula C16H18N2OS.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 160521-72-2
PubChem ID 5311036
InChI Key PYJBJMIBANAOFJ-UHFFFAOYSA-N
Smiles Cl.CC(N)CC1=CNC2=CC=C(OCC3=CC=CS3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 322.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.49 mL 30.97 mL
5 mM 0.62 mL 3.1 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kennett et al (1997) BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 233 PMID: 9144661

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID: 9886683

Duxon et al (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology 36 601 PMID: 9225285

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169


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Keywords: BW 723C86 hydrochloride, BW 723C86 hydrochloride supplier, 5-HT2B, agonist, Serotonin, Receptors, BW723C86, hydrochloride, 1059, Tocris Bioscience

10 Citations for BW 723C86 hydrochloride

Citations are publications that use Tocris products. Selected citations for BW 723C86 hydrochloride include:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103 PMID: 25692021

Tharayil et al (2010) Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil 22 462 PMID: 19941613

Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077


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Reviews for BW 723C86 hydrochloride

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

We used 10nM (5-HT2B partial agonist) BW723C86

PMID: 25692021
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