BW 723C86 hydrochloride

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Cat.No. 1059 - BW 723C86 hydrochloride | C16H18N2OS.HCl | CAS No. 160521-72-2
Description: 5-HT2B agonist
Chemical Name: α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (3)

Biological Activity

Selective 5-HT2B receptor agonist.

Technical Data

M. Wt 322.85
Formula C16H18N2OS.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 160521-72-2
PubChem ID 5311036
InChI Key PYJBJMIBANAOFJ-UHFFFAOYSA-N
Smiles Cl.CC(N)CC1=CNC2=CC=C(OCC3=CC=CS3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kennett et al (1997) BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 233 PMID: 9144661

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID: 9886683

Duxon et al (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology 36 601 PMID: 9225285

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169


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10 Citations for BW 723C86 hydrochloride

Citations are publications that use Tocris products. Selected citations for BW 723C86 hydrochloride include:

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Wouters et al (2009) Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem 284 21177 PMID: 19531484

Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641


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Literature in this Area

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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.