BW 723C86 hydrochloride

Discontinued Product

BW 723C86 hydrochloride (Cat. No. 1059) has been withdrawn from sale for commercial reasons.
Description: 5-HT2B agonist
Chemical Name: α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (11)
Reviews (1)
Literature (2)

Biological Activity for BW 723C86 hydrochloride

BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist.

Technical Data for BW 723C86 hydrochloride

M. Wt 322.85
Formula C16H18N2OS.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 160521-72-2
PubChem ID 5311036
InChI Key PYJBJMIBANAOFJ-UHFFFAOYSA-N
Smiles Cl.CC(N)CC1=CNC2=CC=C(OCC3=CC=CS3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BW 723C86 hydrochloride

Certificate of Analysis / Product Datasheet
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References for BW 723C86 hydrochloride

References are publications that support the biological activity of the product.

Kennett et al (1997) BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 233 PMID: 9144661

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID: 9886683

Duxon et al (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology 36 601 PMID: 9225285

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169

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Keywords: BW 723C86 hydrochloride, BW 723C86 hydrochloride supplier, 5-HT2B, agonist, Serotonin, Receptors, BW723C86, hydrochloride, 1059, Tocris Bioscience

11 Citations for BW 723C86 hydrochloride

Citations are publications that use Tocris products. Selected citations for BW 723C86 hydrochloride include:

Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol 155 343 PMID: 18604238

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395 PMID: 21789169

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103 PMID: 25692021

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728


Reviews for BW 723C86 hydrochloride

Average Rating: 5 (Based on 1 Review.)

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

We used 10nM (5-HT2B partial agonist) BW723C86

PMID: 25692021
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.