Buspirone hydrochloride

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Cat.No. 0962 - Buspirone hydrochloride | C21H31N5O2.HCl | CAS No. 33386-08-2
Description: 5-HT1A partial agonist
Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (5)

Biological Activity

Classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Technical Data

M. Wt 421.97
Formula C21H31N5O2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 33386-08-2
PubChem ID 36431
InChI Key RICLFGYGYQXUFH-UHFFFAOYSA-N
Smiles Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.2 100
water 42.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cao and Rodgers (1997) Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 36 1089 PMID: 9294974

Goa and Ward (1986) Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32 114 PMID: 2874976

Gobert et al (1999) Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i Neuroscience 93 1251 PMID: 10501449

Merck Index 12 1528


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Keywords: Buspirone hydrochloride, Buspirone hydrochloride supplier, 5-HT1A, partial, agonists, Serotonin, Receptors, 0962, Tocris Bioscience

3 Citations for Buspirone hydrochloride

Citations are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:

Gutierrez et al (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Sci Rep 9 3040 PMID: 30816294

Norton and Gutiérrez (2019) The three-spined stickleback as a model for behavioural neuroscience. PLoS One 14 e0213320 PMID: 30913214

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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