Buspirone hydrochloride

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Cat.No. 0962 - Buspirone hydrochloride | C21H31N5O2.HCl | CAS No. 33386-08-2
Description: 5-HT1A partial agonist
Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Technical Data

M. Wt 421.97
Formula C21H31N5O2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 33386-08-2
PubChem ID 36431
InChI Key RICLFGYGYQXUFH-UHFFFAOYSA-N
Smiles Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.2 100
water 42.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cao and Rodgers (1997) Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 36 1089 PMID: 9294974

Goa and Ward (1986) Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32 114 PMID: 2874976

Gobert et al (1999) Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors unde Neuroscience 93 1251 PMID: 10501449

Merck Index 12 1528 PMID:


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Keywords: Buspirone hydrochloride, supplier, 5-HT1A, partial, agonists, Serotonin, Receptors, 5-HT1A, Receptors, Tocris Bioscience

1 Citation for Buspirone hydrochloride

Citations are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655


Do you know of a great paper that uses Buspirone hydrochloride from Tocris? If so please let us know.

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Pathways for Buspirone hydrochloride

Protocols

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