BSI 201

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Cat.No. 5817 - BSI 201 | C7H5IN2O3 | CAS No. 160003-66-7
Description: PARP-1 inhibitor
Alternative Names: Iniparib
Chemical Name: 4-Iodo-3-nitrobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.

Technical Data

M. Wt 292.03
Formula C7H5IN2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 160003-66-7
PubChem ID 9796068
InChI Key MDOJTZQKHMAPBK-UHFFFAOYSA-N
Smiles NC(=O)C1=CC=C(I)C(=C1)[N](=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 14.6 50
DMSO 14.6 50

Preparing Stock Solutions

The following data is based on the product molecular weight 292.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.12 mL 34.24 mL
5 mM 0.68 mL 3.42 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510 PMID: 22128301

Ma et al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590 PMID: 22493268


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Citations for BSI 201

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Literature in this Area

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