BSI 201
Biological Activity
PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.
Technical Data
| M. Wt | 292.03 |
| Formula | C7H5IN2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 160003-66-7 |
| PubChem ID | 9796068 |
| InChI Key | MDOJTZQKHMAPBK-UHFFFAOYSA-N |
| Smiles | NC(=O)C1=CC=C(I)C(=C1)[N](=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.6 | 50 | |
| ethanol | 14.6 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 292.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.12 mL | 34.24 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.85 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Liu et al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510 PMID: 22128301
Ma et al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590 PMID: 22493268
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Keywords: BSI201 iniparib PARP1 inhibitors inhibits poly(ADP-ribose) polymerase cysteine-containing proteins modifiers Iniparib Poly(ADP-ribose) Polymerase
Citations for BSI 201
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