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Submit ReviewBSI 201
Discontinued Product
BSI 201 (Cat. No. 5817) has been withdrawn from sale for commercial reasons.
Description: PARP-1 inhibitor
Alternative Names: Iniparib
Chemical Name: 4-Iodo-3-nitrobenzamide
Purity: ≥98% (HPLC)
Biological Activity for BSI 201
BSI 201 is a PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.
Technical Data for BSI 201
| M. Wt | 292.03 |
| Formula | C7H5IN2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 160003-66-7 |
| PubChem ID | 9796068 |
| InChI Key | MDOJTZQKHMAPBK-UHFFFAOYSA-N |
| Smiles | NC(=O)C1=CC=C(I)C(=C1)[N](=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BSI 201
References for BSI 201
References are publications that support the biological activity of the product.
Liu et al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510 PMID: 22128301
Ma et al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590 PMID: 22493268
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Citations for BSI 201
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Currently there are no citations for BSI 201.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cancer Research Product Guide
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.