BRL 15572 hydrochloride

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Cat.No. 1207 - BRL 15572 hydrochloride | C25H27ClN2O.HCl | CAS No. 1173022-77-9
Description: Selective h5-HT1D antagonist
Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride
Datasheet
Citations (3)
Reviews
Literature (2)

Biological Activity

A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 443.42
Formula C25H27ClN2O.HCl
Storage Desiccate at +4°C
CAS Number 1173022-77-9
PubChem ID 11957475
InChI Key KQGJIKWDFWLCHO-UHFFFAOYSA-N
Smiles Cl.OC(CN1CCN(CC1)C1=CC=CC(Cl)=C1)C(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.43 10
ethanol 22.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 443.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.55 mL 45.1 mL
2.5 mM 0.9 mL 4.51 mL 9.02 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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References

References are publications that support the biological activity of the product.

Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the rat. Eur.J.Pharmacol. 331 169 PMID: 9274976

Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312 PMID: 9303567

Saxena et al (1998) 5-HT1-like receptors: a time to bid goodbye. TiPS 19 311 PMID: 9745358

Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321 PMID: 9303568


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Keywords: BRL 15572 hydrochloride, BRL 15572 hydrochloride supplier, Selective, h5-HT1D, antagonist, Serotonin, Receptors, BRL15572, hydrochloride, GlaxoSmithKline, GSK, 5-HT1D, 1207, Tocris Bioscience

3 Citations for BRL 15572 hydrochloride

Citations are publications that use Tocris products. Selected citations for BRL 15572 hydrochloride include:

McDaid and Docherty (2001) Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. Br J Pharmacol 133 429 PMID: 11375260

Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. World J Gastroenterol 63 362 PMID: 22691374

Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833


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5-HT Receptors Scientific Review

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