BRL 15572 hydrochloride

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Cat.No. 1207 - BRL 15572 hydrochloride | C25H27ClN2O.HCl | CAS No. 1173022-77-9
Description: Selective h5-HT1D antagonist
Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride
Citations (1)

Biological Activity

A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 443.42
Formula C25H27ClN2O.HCl
Storage Desiccate at +4°C
CAS Number 1173022-77-9
PubChem ID 11957475
Smiles Cl.OC(CN1CCN(CC1)C1=CC=CC(Cl)=C1)C(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.43 10
ethanol 22.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 443.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the rat. Eur.J.Pharmacol. 331 169 PMID: 9274976

Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312 PMID: 9303567

Saxena et al (1998) 5-HT1-like receptors: a time to bid goodbye. TiPS 19 311 PMID: 9745358

Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321 PMID: 9303568

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1 Citation for BRL 15572 hydrochloride

Citations are publications that use Tocris products. Selected citations for BRL 15572 hydrochloride include:

Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. World J Gastroenterol 63 362 PMID: 22691374

Do you know of a great paper that uses BRL 15572 hydrochloride from Tocris? If so please let us know.

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