BRD 7389

Pricing Availability Delivery Time Qty
Cat.No. 4037 - BRD 7389 | C24H18N2O2 | CAS No. 376382-11-5
Description: Ribosomal S6 kinase inhibitor
Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.

Compound Libraries

BRD 7389 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 366.41
Formula C24H18N2O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 376382-11-5
PubChem ID 1080352
InChI Key XASCINRGTHLHGM-UHFFFAOYSA-N
Smiles O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fomina-Yadlin et al (2010) Small molecule inducers of insulin expression in pancreatic alpha cells. Proc.Natl.Acad.Sci. USA 107 15099 PMID:


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View all RSK Inhibitors

Keywords: BRD7389 p90 rsk ribosomal s6 kinases inhibitors inhibits rsk1 rsk2 rsk3 RSK

1 Citation for BRD 7389

Citations are publications that use Tocris products. Selected citations for BRD 7389 include:

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705


Do you know of a great paper that uses BRD 7389 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for BRD 7389

Protocols

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