BRD 7389

Pricing Availability   Qty
Cat.No. 4037 - BRD 7389 | C24H18N2O2 | CAS No. 376382-11-5
Description: Ribosomal S6 kinase inhibitor
Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Purity: ≥97% (HPLC)
Citations (1)
Literature (1)

Biological Activity

Ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.

Compound Libraries

BRD 7389 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 366.41
Formula C24H18N2O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 376382-11-5
PubChem ID 1080352
Smiles O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Fomina-Yadlin et al (2010) Small molecule inducers of Ins expression in pancreatic alpha cells. Proc.Natl.Acad.Sci. USA 107 15099

If you know of a relevant reference for BRD 7389, please let us know.

View Related Products by Target

View Related Products by Product Action

View all RSK Inhibitors

Keywords: BRD 7389, BRD 7389 supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, RSK, 4037, Tocris Bioscience

1 Citation for BRD 7389

Citations are publications that use Tocris products. Selected citations for BRD 7389 include:

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705

Do you know of a great paper that uses BRD 7389 from Tocris? Please let us know.

Reviews for BRD 7389

There are currently no reviews for this product. Be the first to review BRD 7389 and earn rewards!

Have you used BRD 7389?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases