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BRD 7389

Cat. No. 4037 3 Citations Submit a Review Datasheet / COA / SDS
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Description: Ribosomal S6 kinase inhibitor
Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BRD 7389

BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.

Technical Data for BRD 7389

M. Wt 366.41
Formula C24H18N2O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 376382-11-5
PubChem ID 1080352
InChI Key XASCINRGTHLHGM-UHFFFAOYSA-N
Smiles O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRD 7389

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.64 100

Preparing Stock Solutions for BRD 7389

The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for BRD 7389

References are publications that support the biological activity of the product.

Fomina-Yadlin et al (2010) Small molecule inducers of Ins expression in pancreatic alpha cells. Proc.Natl.Acad.Sci.U.S.A. 107 15099 PMID: 20696901

If you know of a relevant reference for BRD 7389, please let us know.

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Keywords: BRD 7389, BRD 7389 supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, RSK, 4037, Tocris Bioscience

3 Citations for BRD 7389

Citations are publications that use Tocris products. Selected citations for BRD 7389 include:

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705

Davide et al (2018) Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell 33 91-107.e6 PMID: 29316436

James B et al (2020) Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol 21 857-867 PMID: 32601469

Do you know of a great paper that uses BRD 7389 from Tocris? Please let us know.

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