BRD 7389
Biological Activity
Ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.
Compound Libraries
BRD 7389 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 366.41 |
| Formula | C24H18N2O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 376382-11-5 |
| PubChem ID | 1080352 |
| InChI Key | XASCINRGTHLHGM-UHFFFAOYSA-N |
| Smiles | O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.64 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Fomina-Yadlin et al (2010) Small molecule inducers of insulin expression in pancreatic alpha cells. Proc.Natl.Acad.Sci. USA 107 15099
If you know of a relevant reference for BRD 7389, please let us know.
View Related Products by Product Action
Keywords: BRD 7389, BRD 7389 supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, RSK, 4037, Tocris Bioscience
1 Citation for BRD 7389
Citations are publications that use Tocris products. Selected citations for BRD 7389 include:
Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705
Do you know of a great paper that uses BRD 7389 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
