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Biological Activity for BRD 7389
BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.
Technical Data for BRD 7389
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRD 7389
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BRD 7389
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.73 mL||13.65 mL||27.29 mL|
|5 mM||0.55 mL||2.73 mL||5.46 mL|
|10 mM||0.27 mL||1.36 mL||2.73 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References for BRD 7389
References are publications that support the biological activity of the product.
Fomina-Yadlin et al (2010) Small molecule inducers of Ins expression in pancreatic alpha cells. Proc.Natl.Acad.Sci.U.S.A. 107 15099 PMID: 20696901
If you know of a relevant reference for BRD 7389, please let us know.
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Keywords: BRD 7389, BRD 7389 supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, RSK, 4037, Tocris Bioscience
3 Citations for BRD 7389
Citations are publications that use Tocris products. Selected citations for BRD 7389 include:
Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705
Davide et al (2018) Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell 33 91-107.e6 PMID: 29316436
James B et al (2020) Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol 21 857-867 PMID: 32601469
Do you know of a great paper that uses BRD 7389 from Tocris? Please let us know.
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