BRD 4354

Discontinued Product

BRD 4354 (Cat. No. 6010) has been withdrawn from sale for commercial reasons.
Description: HDAC5 and HDAC9 inhibitor
Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for BRD 4354

BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Technical Data for BRD 4354

M. Wt 382.89
Formula C21H23ClN4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315698-07-8
PubChem ID 3516032
Smiles CCN1CCN(C(C2=C(C3=C(C(Cl)=C2)C=CC=N3)O)C4=CN=CC=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BRD 4354

References are publications that support the biological activity of the product.

Boskovic et al (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 11 1844 PMID: 27064299

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Keywords: BRD 4354, BRD 4354 supplier, BRD4354, HDAC5, HDAC9, selective, histone, deacetylases, inhibitors, inhibits, Class, II, HDACs, 6010, Tocris Bioscience

Citations for BRD 4354

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Currently there are no citations for BRD 4354.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.