BQCA

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Cat.No. 6872 - BQCA | C18H15NO4 | CAS No. 338747-41-4
Description: Positive allosteric modulator of M1 receptors
Chemical Name: 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Muscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.

Technical Data

M. Wt 309.32
Formula C18H15NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 338747-41-4
PubChem ID 1476756
InChI Key BZBBTGCKPRSPGF-UHFFFAOYSA-N
Smiles COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.19 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 16.16 mL 80.82 mL 161.64 mL
1 mM 3.23 mL 16.16 mL 32.33 mL
2 mM 1.62 mL 8.08 mL 16.16 mL
10 mM 0.32 mL 1.62 mL 3.23 mL

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References

References are publications that support the biological activity of the product.

Khajehali et al (2018) Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor. Biochem.Pharmacol 154 243 PMID: 29777683

Ma et al (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 106 15950 PMID: 19717450


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Keywords: BQCA, BQCA supplier, benzyl, quinolone, carboxylic, acid, muscarinic, M1, mAChR, positive, allosteric, modulator, PAM, Receptors, 6872, Tocris Bioscience

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