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Submit ReviewBQCA is a muscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.
M. Wt | 309.32 |
Formula | C18H15NO4 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 338747-41-4 |
PubChem ID | 1476756 |
InChI Key | BZBBTGCKPRSPGF-UHFFFAOYSA-N |
Smiles | COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 6.19 | 20 with gentle warming |
The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 16.16 mL | 80.82 mL | 161.64 mL |
1 mM | 3.23 mL | 16.16 mL | 32.33 mL |
2 mM | 1.62 mL | 8.08 mL | 16.16 mL |
10 mM | 0.32 mL | 1.62 mL | 3.23 mL |
References are publications that support the biological activity of the product.
Khajehali et al (2018) Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor. Biochem.Pharmacol 154 243 PMID: 29777683
Ma et al (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 106 15950 PMID: 19717450
If you know of a relevant reference for BQCA, please let us know.
Keywords: BQCA, BQCA supplier, benzyl, quinolone, carboxylic, acid, muscarinic, M1, mAChR, positive, allosteric, modulator, PAM, Receptors, 6872, Tocris Bioscience
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Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.