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Description: Positive allosteric modulator of M1 receptors
Chemical Name: 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for BQCA
BQCA is a muscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.
Technical Data for BQCA
| M. Wt | 309.32 |
| Formula | C18H15NO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 338747-41-4 |
| PubChem ID | 1476756 |
| InChI Key | BZBBTGCKPRSPGF-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BQCA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.19 | 20 with gentle warming |
Preparing Stock Solutions for BQCA
The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.16 mL | 80.82 mL | 161.64 mL |
| 1 mM | 3.23 mL | 16.16 mL | 32.33 mL |
| 2 mM | 1.62 mL | 8.08 mL | 16.16 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.23 mL |
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Product Datasheets for BQCA
References for BQCA
References are publications that support the biological activity of the product.
Khajehali et al (2018) Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor. Biochem.Pharmacol 154 243 PMID: 29777683
Ma et al (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 106 15950 PMID: 19717450
If you know of a relevant reference for BQCA, please let us know.
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Keywords: BQCA, BQCA supplier, benzyl, quinolone, carboxylic, acid, muscarinic, M1, mAChR, positive, allosteric, modulator, PAM, Receptors, 6872, Tocris Bioscience
Citations for BQCA
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Literature in this Area
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