BNTX maleate

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Cat.No. 0899 - BNTX maleate | C27H27NO4.C4H4O4 | CAS No. 864461-31-4
Description: Standard δ1 selective antagonist
Chemical Name: 7-Benzylidenenaltrexone maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (5)

Biological Activity

Standard selective δ1 opioid receptor antagonist. Also inhibits neurogenic ion transport mediated by a putative novel opioid receptor in porcine ileal mucosa.

Compound Libraries

BNTX maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 545.59
Formula C27H27NO4.C4H4O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 864461-31-4
PubChem ID 71296994
InChI Key GKHUUKGUNNYVGB-LQDKARLYSA-N
Smiles OC(=O)\C=C/C(O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)C\C(=C/C1=CC=CC=C1)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.55 100
water 5.46 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 545.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.16 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hammond et al (1995) Antinociception and d-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. J.Pharmacol.Exp.Ther. 274 1317 PMID: 7562504

Poonyachoti et al (2001) Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic δ- and μ-opioid agonists on neurogenic ion transport in porcine ileal mucosa. J.Pharmacol.Exp.Ther. 297 672 PMID: 11303057

Portoghese et al (1992) A δ1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur.J.Pharmacol. 218 195 PMID: 1327826


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Keywords: BNTX maleate, BNTX maleate supplier, δ1-opioid, delta1-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0899, Tocris Bioscience

1 Citation for BNTX maleate

Citations are publications that use Tocris products. Selected citations for BNTX maleate include:

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. J Cereb Blood Flow Metab 20 RC110 PMID: 11069979


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Reviews for BNTX maleate

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42 perturbagens used the zebrafish DASPEI screen.
By Anonymous on 12/17/2019
Assay Type: In Vivo
Species: Other
Cell Line/Tissue: larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693
review image

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