BNTX maleate

Discontinued Product

BNTX maleate (Cat. No. 0899) has been withdrawn from sale for commercial reasons.
Description: Standard δ1 selective antagonist
Chemical Name: 7-Benzylidenenaltrexone maleate
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for BNTX maleate

BNTX maleate is a standard selective δ1 opioid receptor antagonist. Also inhibits neurogenic ion transport mediated by a putative novel opioid receptor in porcine ileal mucosa.

Technical Data for BNTX maleate

M. Wt 545.59
Formula C27H27NO4.C4H4O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 864461-31-4
PubChem ID 71296994
Smiles OC(=O)\C=C/C(O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)C\C(=C/C1=CC=CC=C1)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BNTX maleate

Certificate of Analysis / Product Datasheet
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References for BNTX maleate

References are publications that support the biological activity of the product.

Hammond et al (1995) Antinociception and d-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. J.Pharmacol.Exp.Ther. 274 1317 PMID: 7562504

Poonyachoti et al (2001) Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic δ- and μ-opioid agonists on neurogenic ion transport in porcine ileal mucosa. J.Pharmacol.Exp.Ther. 297 672 PMID: 11303057

Portoghese et al (1992) A δ1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur.J.Pharmacol. 218 195 PMID: 1327826

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Keywords: BNTX maleate, BNTX maleate supplier, δ1-opioid, delta1-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0899, Tocris Bioscience

1 Citation for BNTX maleate

Citations are publications that use Tocris products. Selected citations for BNTX maleate include:

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. J Cereb Blood Flow Metab 20 RC110 PMID: 11069979

Reviews for BNTX maleate

Average Rating: 5 (Based on 1 Review.)

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42 perturbagens used the zebrafish DASPEI screen.
By Anonymous on 12/17/2019
Assay Type: In Vivo
Species: Other
Cell Line/Tissue: larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.