BMY 7378 dihydrochloride

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Cat.No. 1006 - BMY 7378 dihydrochloride | C22H31N3O3.2HCl | CAS No. 21102-95-4
Description: Selective α1D antagonist
Chemical Name: 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively). Also available as part of the α1-Adrenoceptor Tocriset™.

Technical Data

M. Wt 458.42
Formula C22H31N3O3.2HCl
Storage Store at RT
CAS Number 21102-95-4
PubChem ID 24744861
InChI Key HZRPUQURUAXOHB-UHFFFAOYSA-N
Smiles O=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

References

References are publications that support the biological activity of the product.

Gruel and Glaser (1992) The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 211 211 PMID: 1535319

Piascik et al (1995) The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 275 1583 PMID: 8531132

Sharp et al (1990) Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. Eur.J.Pharmacol. 176 331 PMID: 1970304

Yang and Endoh (1997) Pharmacological evidence for β1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 122 1541 PMID: 9422797


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5 Citations for BMY 7378 dihydrochloride

Citations are publications that use Tocris products. Selected citations for BMY 7378 dihydrochloride include:

Kahn et al (2016) The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Song et al (2010) Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol 299 R1529 PMID: 20881098

Lee et al (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One 5 e14123 PMID: 21152063

Atkins et al (2010) Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS One 5 e12612 PMID: 20830308

Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945


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Literature in this Area

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