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BMS 599626 dihydrochloride
Discontinued ProductBMS 599626 dihydrochloride (Cat. No. 5022) has been withdrawn from sale for commercial reasons.
Biological Activity for BMS 599626 dihydrochloride
BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.
Technical Data for BMS 599626 dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 599626 dihydrochloride
References for BMS 599626 dihydrochloride
References are publications that support the biological activity of the product.
Wong et al (2006) Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin.Cancer Res. 12 6186 PMID: 17062696
Gavai et al (2009) Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficaciou J.Med.Chem. 52 6527 PMID: 19821562
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Citations for BMS 599626 dihydrochloride
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Currently there are no citations for BMS 599626 dihydrochloride.
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Literature in this Area
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