BMS 599626 dihydrochloride

Discontinued Product

BMS 599626 dihydrochloride (Cat. No. 5022) has been withdrawn from sale for commercial reasons.
Description: Potent, selective EGFR and ErbB2 inhibitor
Chemical Name: (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for BMS 599626 dihydrochloride

BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.

Technical Data for BMS 599626 dihydrochloride

M. Wt 603.48
Formula C27H27FN8O3.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1781932-33-9
PubChem ID 90488998
Smiles FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BMS 599626 dihydrochloride

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Citations for BMS 599626 dihydrochloride

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Literature in this Area

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.