Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBMS 599626 dihydrochloride
Discontinued Product
BMS 599626 dihydrochloride (Cat. No. 5022) has been withdrawn from sale for commercial reasons.
Description: Potent, selective EGFR and ErbB2 inhibitor
Chemical Name: (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BMS 599626 dihydrochloride
BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.
Technical Data for BMS 599626 dihydrochloride
| M. Wt | 603.48 |
| Formula | C27H27FN8O3.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1781932-33-9 |
| PubChem ID | 90488998 |
| InChI Key | SKHKFWSXLCGMNF-IKXQUJFKSA-N |
| Smiles | FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 599626 dihydrochloride
References for BMS 599626 dihydrochloride
References are publications that support the biological activity of the product.
Wong et al (2006) Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin.Cancer Res. 12 6186 PMID: 17062696
Gavai et al (2009) Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficaciou J.Med.Chem. 52 6527 PMID: 19821562
View Related Products by Target
View Related Products by Product Action
Keywords: BMS 599626 dihydrochloride, BMS 599626 dihydrochloride supplier, BMS599626, potent, selective, HER1, HER2, EGFR, erbB-2, erbB2, tyrosine, kinase, inhibitors, inhibits, kinases, receptors, growth, factor, Neu, antitumor, antitumour, antiproliferative, 5022, Tocris Bioscience
Citations for BMS 599626 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for BMS 599626 dihydrochloride.
Reviews for BMS 599626 dihydrochloride
There are currently no reviews for this product. Be the first to review BMS 599626 dihydrochloride and earn rewards!
Have you used BMS 599626 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Angiogenesis in Cancer PosterUpdated
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.