BMS 453

Pricing Availability Delivery Time Qty
Cat.No. 3409 - BMS 453 | C27H24O2 | CAS No. 166977-43-1
Description: Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
Alternative Names: BMS 189453
Chemical Name: 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Compound Libraries

BMS 453 is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 380.48
Formula C27H24O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 166977-43-1
PubChem ID 9875424
InChI Key VUODRPPTYLBGFM-CMDGGOBGSA-N
Smiles CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 380.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (1995) RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 14 1187 PMID: 7720709

Yang et al (2001) The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest. Oncogene 20 8025 PMID: 11753686

Monteiro et al (2009) Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. Stem Cells Dev. 18 457 PMID: 18690793


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Keywords: BMS 453, supplier, BMS453, retinoic, acid, receptors, RARβ, RARα, RARγ, RARalpha, RARbeta, RARgamma, RARa, RARb, RARg, agonists, antagonists, BMS189453, BMS, 189453, Retinoic, Acid, Receptors, Tocris Bioscience

Citations for BMS 453

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Literature in this Area

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Retinoid Receptors Scientific Review

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Pathways for BMS 453

Protocols

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