BMS 453

Discontinued Product

BMS 453 (Cat. No. 3409) has been withdrawn from sale for commercial reasons.
Description: Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
Alternative Names: BMS 189453
Chemical Name: 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Purity: ≥98% (HPLC)
Citations (3)
Literature (2)

Biological Activity for BMS 453

BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Technical Data for BMS 453

M. Wt 380.48
Formula C27H24O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 166977-43-1
PubChem ID 9875424
Smiles CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BMS 453

Certificate of Analysis / Product Datasheet
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Keywords: BMS 453, BMS 453 supplier, BMS453, retinoic, acid, receptors, RARβ, RARα, RARγ, RARalpha, RARbeta, RARgamma, RARa, RARb, RARg, agonists, antagonists, BMS189453, BMS, 189453, Retinoic, Acid, Receptors, 3409, Tocris Bioscience

3 Citations for BMS 453

Citations are publications that use Tocris products. Selected citations for BMS 453 include:

Naylor et al (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun 7 12197 PMID: 27406002

Mizee et al (2013) Retinoic acid induces blood-brain barrier development. J Neurosci 33 1660 PMID: 23345238

Wahl et al (2018) Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics 19 795 PMID: 30390632

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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