BMS 453

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Cat.No. 3409 - BMS 453 | C27H24O2 | CAS No. 166977-43-1
Description: Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
Alternative Names: BMS 189453
Chemical Name: 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Purity: ≥98% (HPLC)
Citations (3)
Literature (3)

Biological Activity for BMS 453

BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Technical Data for BMS 453

M. Wt 380.48
Formula C27H24O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 166977-43-1
PubChem ID 9875424
Smiles CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 453

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.05 100

Preparing Stock Solutions for BMS 453

The following data is based on the product molecular weight 380.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for BMS 453

Certificate of Analysis / Product Datasheet
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References for BMS 453

References are publications that support the biological activity of the product.

Chen et al (1995) RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 14 1187 PMID: 7720709

Yang et al (2001) The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest. Oncogene 20 8025 PMID: 11753686

Monteiro et al (2009) Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. Stem Cells Dev. 18 457 PMID: 18690793

If you know of a relevant reference for BMS 453, please let us know.

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Keywords: BMS 453, BMS 453 supplier, BMS453, retinoic, acid, receptors, RARβ, RARα, RARγ, RARalpha, RARbeta, RARgamma, RARa, RARb, RARg, agonists, antagonists, BMS189453, BMS, 189453, Retinoic, Acid, Receptors, 3409, Tocris Bioscience

3 Citations for BMS 453

Citations are publications that use Tocris products. Selected citations for BMS 453 include:

Wahl et al (2018) Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics 19 795 PMID: 30390632

Mizee et al (2013) Retinoic acid induces blood-brain barrier development. J Neurosci 33 1660 PMID: 23345238

Naylor et al (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun 7 12197 PMID: 27406002

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Literature in this Area

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