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Potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC50 values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 345.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.79 mL||28.96 mL||57.91 mL|
|2.5 mM||1.16 mL||5.79 mL||11.58 mL|
|5 mM||0.58 mL||2.9 mL||5.79 mL|
|25 mM||0.12 mL||0.58 mL||1.16 mL|
References are publications that support the biological activity of the product.
Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405 PMID: 12824044
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.