BMS 195614

Pricing Availability   Qty
Description: Selective RARα antagonist
Alternative Names: BMS614
Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (1)

Biological Activity for BMS 195614

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Technical Data for BMS 195614

M. Wt 448.51
Formula C29H24N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 182135-66-6
PubChem ID 445091
InChI Key WGLMBRZXZDAQHP-UHFFFAOYSA-N
Smiles O=C(NC4=CC=C(C(O)=O)C=C4)C3=CC1=C(C=C3)C(C)(C)CC=C1C2=CN=C(C=CC=C5)C5=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 195614

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.21 25

Preparing Stock Solutions for BMS 195614

The following data is based on the product molecular weight 448.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.92 mL 44.59 mL 89.18 mL
1.25 mM 1.78 mL 8.92 mL 17.84 mL
2.5 mM 0.89 mL 4.46 mL 8.92 mL
12.5 mM 0.18 mL 0.89 mL 1.78 mL

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Product Datasheets for BMS 195614

Certificate of Analysis / Product Datasheet
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References for BMS 195614

References are publications that support the biological activity of the product.

Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519 PMID: 10421757

Germain et al (2009) Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 16 479 PMID: 19477412

Schoenermark et al (1999) Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci. 30 878


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Keywords: BMS 195614, BMS 195614 supplier, BMS195614, retinoic, acid, receptor, RAR, alpha, α, RARa, antagonists, neutral, selective, BMS614, 253310-42-8, Retinoic, Acid, Receptors, 3660, Tocris Bioscience

8 Citations for BMS 195614

Citations are publications that use Tocris products. Selected citations for BMS 195614 include:

Mickaël M et al (2020) A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Rep 30 914-931.e9 PMID: 31968263

Metzler et al (2018) RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development 145 PMID: 29986869

Gerald et al (2016) All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages. PLoS One 11 e0168072 PMID: 27977740

Flamini et al (2014) Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med 18 1113 PMID: 24720764


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.