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Biological Activity for BMS 191011
BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
Compound Libraries for BMS 191011
Technical Data for BMS 191011
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BMS 191011
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BMS 191011
The following data is based on the product molecular weight 370.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.7 mL||13.49 mL||26.98 mL|
|5 mM||0.54 mL||2.7 mL||5.4 mL|
|10 mM||0.27 mL||1.35 mL||2.7 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for BMS 191011
References are publications that support the biological activity of the product.
Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528 PMID: 17266205
Hewawasam et al (2003) Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts. 13 1695
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Keywords: BMS 191011, BMS 191011 supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011, activators, Ca2+-Activated, 2665, Tocris Bioscience
3 Citations for BMS 191011
Citations are publications that use Tocris products. Selected citations for BMS 191011 include:
Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101 PMID: 23653115
Shukla et al (2014) Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol 307 H134 PMID: 24816259
Eroglu et al (2012) Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. Int J Neuropsychopharmacol 287 15886 PMID: 22418437
Do you know of a great paper that uses BMS 191011 from Tocris? Please let us know.
Reviews for BMS 191011
Average Rating: 5 (Based on 1 Review.)
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The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.
Dissolve in DMSO
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.