Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 370.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.7 mL||13.49 mL||26.98 mL|
|5 mM||0.54 mL||2.7 mL||5.4 mL|
|10 mM||0.27 mL||1.35 mL||2.7 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the products' biological activity.
Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528 PMID: 17266205
If you know of a relevant reference for BMS 191011, please let us know.
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Keywords: BMS 191011, supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011, activators, Ca2+-Activated, Potassium, Channels, Ca2+-Activated, Potassium, Channels, Tocris Bioscience
2 Citations for BMS 191011
Citations are publications that use Tocris products. Selected citations for BMS 191011 include:
Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101 PMID: 23653115
Eroglu et al (2012) Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. Int J Neuropsychopharmacol 287 15886 PMID: 22418437
Do you know of a great paper that uses BMS 191011 from Tocris? If so please let us know.
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New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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