BMS 191011

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Cat.No. 2665 - BMS 191011 | C16H10ClF3N2O3 | CAS No. 202821-81-6
Description: Potent BKCa (KCa1.1) channel opener
Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (2)

Biological Activity

Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Compound Libraries

BMS 191011 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 370.71
Formula C16H10ClF3N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 202821-81-6
PubChem ID 10474339
InChI Key QKOWACXSXTXRKA-UHFFFAOYSA-N
Smiles OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.07 100
ethanol 5.56 15

Preparing Stock Solutions

The following data is based on the product molecular weight 370.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.49 mL 26.98 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528 PMID: 17266205

Hewawasam et al (2003) Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts. 13 1695


If you know of a relevant reference for BMS 191011, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: BMS 191011, BMS 191011 supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011, activators, Ca2+-Activated, 2665, Tocris Bioscience

3 Citations for BMS 191011

Citations are publications that use Tocris products. Selected citations for BMS 191011 include:

Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101 PMID: 23653115

Shukla et al (2014) Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol 307 H134 PMID: 24816259

Eroglu et al (2012) Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. Int J Neuropsychopharmacol 287 15886 PMID: 22418437


Do you know of a great paper that uses BMS 191011 from Tocris? Please let us know.

Reviews for BMS 191011

Average Rating: 5 (Based on 1 Review.)

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BK channel activator with great research potential.
By Anonymous on 10/29/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.

Dissolve in DMSO

review image

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