BML-190

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Cat.No. 1383 - BML-190 | C23H23ClN2O4 | CAS No. 2854-32-2
Description: Potent, selective CB2 ligand
Alternative Names: Indomethacin morpholinylamide, IMMA
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively).

Technical Data

M. Wt 426.9
Formula C23H23ClN2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2854-32-2
PubChem ID 2415
InChI Key BJSDNVVWJYDOLK-UHFFFAOYSA-N
Smiles COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(=O)N3CCOCC3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.69 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.71 mL 23.42 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Melck et al (2000) Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141 118 PMID: 10614630

Gallant et al (1996) New class of potent ligands for the human peripheral cannabinoid receptor. Bioorg.Med.Chem.Lett. 6 2263 PMID:


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Keywords: Potent selective CB2 ligands Cannabinoid Receptors cb2r Indomethacin morpholinylamide IMMA CB2 Receptors

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