BIM, Biotinylated

Pricing Availability Delivery Time Qty
Cat.No. 3526 - BIM, Biotinylated | (Biotin)-β-Ala-β-Ala-Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg-NH2
Description: Bim peptide fragment
Datasheet
Citations
Literature
Pathways

Biological Activity

Bim peptide fragment (residues 81-106) with a biotin moiety attached.

Technical Data

M. Wt 3637.14
Formula C161H247N49O44S2
Sequence AADMRPEIWIAQELRRIGDEFNAYYARR

(Modifications: Ala-1 = (Biotin)-β-Ala, Ala-2 = β-Ala, Arg-28 = C-terminal amide)

Storage Store at -20°C
PubChem ID 90488855
InChI Key PSNCGLAAPGGYMJ-YLKYZDBHSA-N
Smiles [H]N(CCC(=O)NCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(=O)CCCC[C@@H]1SC[C@]2([H])NC(=O)N[C@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 3637.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.27 mL 1.37 mL 2.75 mL
5 mM 0.05 mL 0.27 mL 0.55 mL
10 mM 0.03 mL 0.14 mL 0.27 mL
50 mM 0.01 mL 0.03 mL 0.05 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Whitfield et al (2003) High-throughput methods to detect dimerization of Bcl-2 family proteins. Anal.Biochem. 322 170 PMID: 14596824

Wang et al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139 PMID: 17034116


If you know of a relevant reference for BIM, Biotinylated, please let us know.

View Related Products by Target

Keywords: Bim peptide fragment Bcl-2 Family Bcl-2 Family

Citations for BIM, Biotinylated

Citations are publications that use Tocris products.

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Literature in this Area

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Programmed Cell Death Poster

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Pathways for BIM, Biotinylated

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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