Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBIM 23127
Discontinued Product
BIM 23127 (Cat. No. 1839) has been withdrawn from sale for commercial reasons.
Description: NMB receptor antagonist. Also U-II receptor antagonist
Biological Activity for BIM 23127
Neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA2 = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.
Technical Data for BIM 23127
| M. Wt | 1178.43 |
| Formula | C62H71N11O9S2 |
| Sequence |
XCYWXVCX (Modifications: X-1 = D-Nal, Trp-3 = D-Trp, X-5 = Orn, X-8 = Nal & C-terminal amide, Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 160161-61-5 |
| Smiles | [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BIM 23127
References for BIM 23127
References are publications that support the biological activity of the product.
Herold et al (2003) The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br.J.Pharmacol. 139 203 PMID: 12770925
Ladenheim et al (1994) Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur.J.Pharmacol. 271 R7 PMID: 7698191
Santo-Yamada et al (2003) Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Neurosci.Lett. 340 65 PMID: 12648760
View Related Products by Target
View Related Products by Product Action
Keywords: BIM 23127, BIM 23127 supplier, U-II, receptor, antagonists, NMB, UT, Receptors, Urotensin-II, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23127, 1839, Tocris Bioscience
Citations for BIM 23127
Citations are publications that use Tocris products.
Currently there are no citations for BIM 23127.
Reviews for BIM 23127
There are currently no reviews for this product. Be the first to review BIM 23127 and earn rewards!
Have you used BIM 23127?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.