Discontinued ProductUnfortunately BIM 23127 (Cat. No. 1839) has been withdrawn from sale for commercial reasons.
Neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA2 = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.
(Modifications: X-1 = D-Nal, Trp-3 = D-Trp, X-5 = Orn, X-8 = Nal & C-terminal amide, Disulfide bridge between 2 - 7)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1178.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.24 mL||8.49 mL|
|5 mM||0.17 mL||0.85 mL||1.7 mL|
|10 mM||0.08 mL||0.42 mL||0.85 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the products' biological activity.
Herold et al (2003) The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br.J.Pharmacol. 139 203 PMID: 12770925
Ladenheim et al (1994) Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur.J.Pharmacol. 271 R7 PMID: 7698191
Santo-Yamada et al (2003) Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Neurosci.Lett. 340 65 PMID: 12648760
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Keywords: BIM 23127, supplier, U-II, receptor, antagonists, NMB, UT, Receptors, Urotensin-II, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23127, Bombesin, Receptors, Urotensin-II, Receptors, Bombesin, Receptors, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.