Discontinued ProductUnfortunately BIM 23127 (Cat. No. 1839) has been withdrawn from sale for commercial reasons.
Neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA2 = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.
(Modifications: X-1 = D-Nal, Trp-3 = D-Trp, X-5 = Orn, X-8 = Nal & C-terminal amide, Disulfide bridge between 2 - 7)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1178.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.24 mL||8.49 mL|
|5 mM||0.17 mL||0.85 mL||1.7 mL|
|10 mM||0.08 mL||0.42 mL||0.85 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the products' biological activity.
Herold et al (2003) The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br.J.Pharmacol. 139 203 PMID: 12770925
Ladenheim et al (1994) Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur.J.Pharmacol. 271 R7 PMID: 7698191
Santo-Yamada et al (2003) Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Neurosci.Lett. 340 65 PMID: 12648760
View Related Products by Product Action
Keywords: BIM 23127, supplier, U-II, receptor, antagonists, NMB, UT, Receptors, Urotensin-II, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23127, Bombesin, Receptors, Urotensin-II, Receptors, Bombesin, Receptors, Tocris Bioscience
Citations for BIM 23127
Citations are publications that use Tocris products.
Currently there are no citations for BIM 23127.
Reviews for BIM 23127
There are currently no reviews for this product. Be the first to review BIM 23127 and earn rewards!
Have you used BIM 23127?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.