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Submit ReviewBIM 23127
Discontinued Product
BIM 23127 (Cat. No. 1839) has been withdrawn from sale for commercial reasons.
Description: NMB receptor antagonist. Also U-II receptor antagonist
Biological Activity for BIM 23127
Neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA2 = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.
Technical Data for BIM 23127
| M. Wt | 1178.43 |
| Formula | C62H71N11O9S2 |
| Sequence |
XCYWXVCX (Modifications: X-1 = D-Nal, Trp-3 = D-Trp, X-5 = Orn, X-8 = Nal & C-terminal amide, Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 160161-61-5 |
| Smiles | [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BIM 23127
References for BIM 23127
References are publications that support the biological activity of the product.
Herold et al (2003) The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br.J.Pharmacol. 139 203 PMID: 12770925
Ladenheim et al (1994) Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur.J.Pharmacol. 271 R7 PMID: 7698191
Santo-Yamada et al (2003) Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Neurosci.Lett. 340 65 PMID: 12648760
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Keywords: BIM 23127, BIM 23127 supplier, U-II, receptor, antagonists, NMB, UT, Receptors, Urotensin-II, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23127, 1839, Tocris Bioscience
Citations for BIM 23127
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